Total Synthesis of Bistramide A

Total Synthesis of Bistramide A

An asymmetric synthesis of the marine metabolite bistramide A is reported. The synthesis relies on the utility of three different organosilane reagents to construct all principle fragments and 8 of the 11 stereogenic centers of the natural product.

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Veröffentlicht in:Organic letters 2007-01, Vol.9 (2), p.327-330
Hauptverfasser: Lowe, Jason T, Wrona, Iwona E, Panek, James S
Format: Artikel
Sprache:eng
Schlagworte:
Acetamides - chemical synthesis
Acetamides - chemistry
Molecular Conformation
Pyrans - chemical synthesis
Pyrans - chemistry
Spiro Compounds - chemical synthesis
Spiro Compounds - chemistry
Stereoisomerism
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Beschreibung
Zusammenfassung:An asymmetric synthesis of the marine metabolite bistramide A is reported. The synthesis relies on the utility of three different organosilane reagents to construct all principle fragments and 8 of the 11 stereogenic centers of the natural product.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol062957y