Towards erythropoietin mimicking small molecules

Design, synthesis and preliminary biological activity of small molecular weight EPO agonists is reported. Small molecules potentially mimicking the hormone erythropoietin have been discovered by screening of a library of rationally designed multicomponent reaction molecules in a functional cell-base...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2007-01, Vol.17 (2), p.379-384
Hauptverfasser:	Dömling, Alexander, Beck, Barbara, Baumbach, William, Larbig, Gregor
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell Line, Tumor Cell Proliferation - drug effects Cell Survival - drug effects Combinatorial chemistry Design Drug Design Drug Evaluation, Preclinical Erythropoietin Erythropoietin - chemistry Humans IMCR Interleukin-3 - physiology Isocyanide Medical sciences Mice Miscellaneous Models, Molecular Molecular Conformation Molecular Mimicry Passerini Pharmacology. Drug treatments Receptors, Erythropoietin - drug effects Recombinant Proteins Ugi
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Beschreibung
Zusammenfassung:	Design, synthesis and preliminary biological activity of small molecular weight EPO agonists is reported. Small molecules potentially mimicking the hormone erythropoietin have been discovered by screening of a library of rationally designed multicomponent reaction molecules in a functional cell-based assay.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2006.10.040