Serendipitous discovery of novel imidazolopyrazole scaffold as selective androgen receptor modulators
A novel imidazolopyrazole derivative has been fortuitously discovered as potent selective androgen receptor modulator with in vivo efficacy. A novel imidazolopyrazole derivative has been fortuitously discovered as potent selective androgen receptor modulator with in vivo efficacy.
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| Veröffentlicht in: | Bioorganic & medicinal chemistry letters 2007-01, Vol.17 (2), p.439-443 |
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| container_end_page | 443 |
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| container_issue | 2 |
| container_start_page | 439 |
| container_title | Bioorganic & medicinal chemistry letters |
| container_volume | 17 |
| creator | Zhang, Xuqing Li, Xiaojie Allan, George F. Sbriscia, Tifanie Linton, Olivia Lundeen, Scott G. Sui, Zhihua |
| description | A novel imidazolopyrazole derivative has been fortuitously discovered as potent selective androgen receptor modulator with in vivo efficacy.
A novel imidazolopyrazole derivative has been fortuitously discovered as potent selective androgen receptor modulator with in vivo efficacy. |
| doi_str_mv | 10.1016/j.bmcl.2006.10.035 |
| format | Article |
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A novel imidazolopyrazole derivative has been fortuitously discovered as potent selective androgen receptor modulator with in vivo efficacy.</description><subject>Animals</subject><subject>Binding, Competitive - drug effects</subject><subject>Biological and medical sciences</subject><subject>Crystallography, X-Ray</subject><subject>Hormones. Endocrine system</subject><subject>Imidazolopyrazole</subject><subject>In Vitro Techniques</subject><subject>Indicators and Reagents</subject><subject>Ligands</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Miscellaneous</subject><subject>Models, Molecular</subject><subject>Muscle, Skeletal - drug effects</subject><subject>Orchiectomy</subject><subject>Organ Size</subject><subject>Pharmacology. Drug treatments</subject><subject>Prostate - drug effects</subject><subject>Pyrazoles - chemical synthesis</subject><subject>Pyrazoles - pharmacology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Receptors, Androgen - drug effects</subject><subject>SARMs</subject><subject>Structure-Activity Relationship</subject><subject>Testosterone - metabolism</subject><subject>Tissue selectivity</subject><issn>0960-894X</issn><issn>1464-3405</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE2LFDEQQIMo7rj6BzxILu6tx0on3UmDF1l2VVjw4C54C5mkIhnSnTbpGRh_vWlmYG-e6oNXRdUj5D2DLQPWf9pvd6ON2xagr40t8O4F2TDRi4YL6F6SDQw9NGoQv67Im1L2AEyAEK_JFZMgh1psCP7EjJMLc1jSoVAXik1HzCeaPJ1qFmkYgzN_U0zzKa8RabHG-xQdNYUWjGiXcERqJpfTb5xoRovzkjIdkztEU7PylrzyJhZ8d4nX5On-7vH2W_Pw4-v32y8PjeVKLI2UChE8EztuwCtud4MCibK1zg0omOk6yV09XLIBTa3Q8laonjPhpbOSX5Ob8945pz8HLIse60MYo5mwvqd7JVpQqq1gewZtTqVk9HrOYTT5pBnoVa7e61WuXuWuvSq3Dn24bD_sRnTPIxebFfh4AUx1FH02kw3lmVOiZ203VO7zmcPq4hgw62IDThZdqPIW7VL43x3_ADv8moA</recordid><startdate>20070115</startdate><enddate>20070115</enddate><creator>Zhang, Xuqing</creator><creator>Li, Xiaojie</creator><creator>Allan, George F.</creator><creator>Sbriscia, Tifanie</creator><creator>Linton, Olivia</creator><creator>Lundeen, Scott G.</creator><creator>Sui, Zhihua</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070115</creationdate><title>Serendipitous discovery of novel imidazolopyrazole scaffold as selective androgen receptor modulators</title><author>Zhang, Xuqing ; Li, Xiaojie ; Allan, George F. ; Sbriscia, Tifanie ; Linton, Olivia ; Lundeen, Scott G. ; Sui, Zhihua</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c384t-778ee0f14b3a0f83cb9807e72cdd9e41a5573d914719eaa55ec32486314f7dc73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Animals</topic><topic>Binding, Competitive - drug effects</topic><topic>Biological and medical sciences</topic><topic>Crystallography, X-Ray</topic><topic>Hormones. Endocrine system</topic><topic>Imidazolopyrazole</topic><topic>In Vitro Techniques</topic><topic>Indicators and Reagents</topic><topic>Ligands</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Miscellaneous</topic><topic>Models, Molecular</topic><topic>Muscle, Skeletal - drug effects</topic><topic>Orchiectomy</topic><topic>Organ Size</topic><topic>Pharmacology. 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A novel imidazolopyrazole derivative has been fortuitously discovered as potent selective androgen receptor modulator with in vivo efficacy.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>17079140</pmid><doi>10.1016/j.bmcl.2006.10.035</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 0960-894X |
| ispartof | Bioorganic & medicinal chemistry letters, 2007-01, Vol.17 (2), p.439-443 |
| issn | 0960-894X 1464-3405 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68420882 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Binding, Competitive - drug effects Biological and medical sciences Crystallography, X-Ray Hormones. Endocrine system Imidazolopyrazole In Vitro Techniques Indicators and Reagents Ligands Male Medical sciences Miscellaneous Models, Molecular Muscle, Skeletal - drug effects Orchiectomy Organ Size Pharmacology. Drug treatments Prostate - drug effects Pyrazoles - chemical synthesis Pyrazoles - pharmacology Rats Rats, Sprague-Dawley Receptors, Androgen - drug effects SARMs Structure-Activity Relationship Testosterone - metabolism Tissue selectivity |
| title | Serendipitous discovery of novel imidazolopyrazole scaffold as selective androgen receptor modulators |
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