Serendipitous discovery of novel imidazolopyrazole scaffold as selective androgen receptor modulators

A novel imidazolopyrazole derivative has been fortuitously discovered as potent selective androgen receptor modulator with in vivo efficacy. A novel imidazolopyrazole derivative has been fortuitously discovered as potent selective androgen receptor modulator with in vivo efficacy.

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Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2007-01, Vol.17 (2), p.439-443
Hauptverfasser:	Zhang, Xuqing, Li, Xiaojie, Allan, George F., Sbriscia, Tifanie, Linton, Olivia, Lundeen, Scott G., Sui, Zhihua
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding, Competitive - drug effects Biological and medical sciences Crystallography, X-Ray Hormones. Endocrine system Imidazolopyrazole In Vitro Techniques Indicators and Reagents Ligands Male Medical sciences Miscellaneous Models, Molecular Muscle, Skeletal - drug effects Orchiectomy Organ Size Pharmacology. Drug treatments Prostate - drug effects Pyrazoles - chemical synthesis Pyrazoles - pharmacology Rats Rats, Sprague-Dawley Receptors, Androgen - drug effects SARMs Structure-Activity Relationship Testosterone - metabolism Tissue selectivity
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Beschreibung
Zusammenfassung:	A novel imidazolopyrazole derivative has been fortuitously discovered as potent selective androgen receptor modulator with in vivo efficacy. A novel imidazolopyrazole derivative has been fortuitously discovered as potent selective androgen receptor modulator with in vivo efficacy.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2006.10.035