Molecular cloning and characterization of WD40-repeat protein from Clonorchis sinensis

WD40-repeat proteins have four to eight repeating units flanked by Gly-His (GH) and Trp-Asp (WD) at both termini and folds into a beta-propeller. A polypeptide deduced from a Clonorchis sinensis cDNA clone analyzed to have seven WD40-repeats and predicted to form a beta-propeller (CsWD1). The CsWD1...

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Veröffentlicht in:	Parasitology research (1987) 2007-12, Vol.102 (1), p.53-56
Hauptverfasser:	PYO YUN CHO, TEA IM KIM, YONG JE CHUNG, LOVERDE, Philip T, OSMAN, Ahmed, WON GI YOO, SHUNYU LI, HONG, Sung-Jong, TAE YUN KIM, YOUNG SOON PARK, SONG, Kye-Yong, CHOI, Min-Ho, HONG, Sung-Tae
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Biological and medical sciences Cloning, Molecular Clonorchis sinensis Clonorchis sinensis - metabolism DNA, Complementary - genetics Fundamental and applied biological sciences. Psychology Gene Expression Regulation - physiology General aspects General aspects and techniques. Study of several systematic groups. Models Helminth Proteins - chemistry Helminth Proteins - genetics Helminth Proteins - metabolism Invertebrates Molecular Sequence Data
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Zusammenfassung:	WD40-repeat proteins have four to eight repeating units flanked by Gly-His (GH) and Trp-Asp (WD) at both termini and folds into a beta-propeller. A polypeptide deduced from a Clonorchis sinensis cDNA clone analyzed to have seven WD40-repeats and predicted to form a beta-propeller (CsWD1). The CsWD1 protein was expressed stage-specifically in the metacercariae and localized in the tegumental syncytium. The CsWD1 protein is suggested to serve as a platform for interacting partner proteins in the tegumental syncytium of C. sinensis metacercariae.
ISSN:	0932-0113 1432-1955
DOI:	10.1007/s00436-007-0721-6