Comparison of the long-term histopathologic and morphologic changes after endometrial rollerball ablation and resection: A prospective randomized trial

Abstract Study objective To compare long-term histologic features of endometrial rollerball ablation versus resection. Design Randomized clinical trial (Canadian Task Force classification I). Setting Akdeniz University School of Medicine. Patients Women with menorrhagia undergoing endometrial ablation. Intervention Comparison of patients with menorrhagia undergoing endometrial resection and ablation. Measurements and main results Endometrial rollerball ablation (n = 23 women) and resection (n = 25) were followed by second-look office hysteroscopy with endometrial biopsy. Mean follow-up to second look hysteroscopy after rollerball ablation and loop resection was 33.4 ± 2.1 and 31.1 ± 2.6 months, respectively. Complete atrophy and partial adhesion or obliteration of the cavity and fibrosis were observed at second-look hysteroscopy and were similar in both groups. Whereas all random biopsy specimens after both ablation and resection revealed diminished endometrial glands with varied necrosis and scarring, the number of endometrial glands per field was not correlated with amount of bleeding or menstrual pattern. Bleeding patterns were similar between the groups. No precancerous or malignant lesion was found after the procedures. Conclusion Although efficacy of both endometrial ablation and resection is related to initial thermal destruction and correlated with postablation hysteroscopic and histologic findings, endometrial regrowth may be expected and is not a failure of ablation. Both procedures revealed histopathologically and clinically similar results.