Intensity of Statin Therapy in Relation to Myocardial Ischemia, Troponin T Release, and Clinical Cardiac Outcome in Patients Undergoing Major Vascular Surgery
Intensity of Statin Therapy in Relation to Myocardial Ischemia, Troponin T Release, and Clinical Cardiac Outcome in Patients Undergoing Major Vascular Surgery Harm H. H. Feringa, Olaf Schouten, Stefanos E. Karagiannis, Jasper Brugts, Abdou Elhendy, Eric Boersma, Radosav Vidakovic, Marc R.H.M. van Sa...
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| Veröffentlicht in: | Journal of the American College of Cardiology 2007-10, Vol.50 (17), p.1649-1656 |
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| creator | Feringa, Harm H.H., MD Schouten, Olaf, MD Karagiannis, Stefanos E., MD Brugts, Jasper, MD Elhendy, Abdou, MD Boersma, Eric, PhD Vidakovic, Radosav, MD van Sambeek, Marc R.H.M., MD Noordzij, Peter G., MD Bax, Jeroen J., MD Poldermans, Don, MD |
| description | Intensity of Statin Therapy in Relation to Myocardial Ischemia, Troponin T Release, and Clinical Cardiac Outcome in Patients Undergoing Major Vascular Surgery Harm H. H. Feringa, Olaf Schouten, Stefanos E. Karagiannis, Jasper Brugts, Abdou Elhendy, Eric Boersma, Radosav Vidakovic, Marc R.H.M. van Sambeek, Peter G. Noordzij, Jeroen J. Bax, Don Poldermans The cardioprotective effects of statins in patients undergoing major vascular surgery remain not well defined. In a prospective study of 359 patients, statin dose and cholesterol levels were recorded before major vascular surgery. In multivariate analysis, lower low-density lipoprotein cholesterol correlated with lower myocardial ischemia, troponin T release, and 30-day and late cardiac events. Higher statin doses (expressed as percentage of maximum recommended therapeutic dose) correlated with lower myocardial ischemia, troponin T release, and 30-day and late cardiac events, even after adjusting for low-density lipoprotein cholesterol. Significantly higher perioperative heart rate variability was observed in patients with higher statin doses. |
| doi_str_mv | 10.1016/j.jacc.2007.06.046 |
| format | Article |
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H. Feringa, Olaf Schouten, Stefanos E. Karagiannis, Jasper Brugts, Abdou Elhendy, Eric Boersma, Radosav Vidakovic, Marc R.H.M. van Sambeek, Peter G. Noordzij, Jeroen J. Bax, Don Poldermans The cardioprotective effects of statins in patients undergoing major vascular surgery remain not well defined. In a prospective study of 359 patients, statin dose and cholesterol levels were recorded before major vascular surgery. In multivariate analysis, lower low-density lipoprotein cholesterol correlated with lower myocardial ischemia, troponin T release, and 30-day and late cardiac events. Higher statin doses (expressed as percentage of maximum recommended therapeutic dose) correlated with lower myocardial ischemia, troponin T release, and 30-day and late cardiac events, even after adjusting for low-density lipoprotein cholesterol. Significantly higher perioperative heart rate variability was observed in patients with higher statin doses.</description><identifier>ISSN: 0735-1097</identifier><identifier>EISSN: 1558-3597</identifier><identifier>DOI: 10.1016/j.jacc.2007.06.046</identifier><identifier>PMID: 17950146</identifier><identifier>CODEN: JACCDI</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Aged ; Biological and medical sciences ; Biomarkers - metabolism ; Cardiology ; Cardiology. Vascular system ; Cardiovascular ; Cholesterol ; Cholesterol, LDL - drug effects ; Cholesterol, LDL - metabolism ; Coronary heart disease ; Dose-Response Relationship, Drug ; Female ; Heart ; Heart attacks ; Heart Rate - drug effects ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage ; Internal Medicine ; Low density lipoprotein ; Male ; Medical sciences ; Multivariate Analysis ; Myocardial Ischemia - diagnosis ; Myocardial Ischemia - metabolism ; Myocarditis. Cardiomyopathies ; Outcome Assessment (Health Care) ; Prospective Studies ; Statins ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Troponin T - drug effects ; Troponin T - secretion ; Vascular surgery: aorta, extremities, vena cava. Surgery of the lymphatic vessels ; Vascular Surgical Procedures</subject><ispartof>Journal of the American College of Cardiology, 2007-10, Vol.50 (17), p.1649-1656</ispartof><rights>American College of Cardiology Foundation</rights><rights>2007 American College of Cardiology Foundation</rights><rights>2007 INIST-CNRS</rights><rights>Copyright Elsevier Limited Oct 23, 2007</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c503t-499fee6d29ed075f66dd1763bab13ea09e344e149db8c33a62b74d01b300c4713</citedby><cites>FETCH-LOGICAL-c503t-499fee6d29ed075f66dd1763bab13ea09e344e149db8c33a62b74d01b300c4713</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0735109707023947$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19174868$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17950146$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Feringa, Harm H.H., MD</creatorcontrib><creatorcontrib>Schouten, Olaf, MD</creatorcontrib><creatorcontrib>Karagiannis, Stefanos E., MD</creatorcontrib><creatorcontrib>Brugts, Jasper, MD</creatorcontrib><creatorcontrib>Elhendy, Abdou, MD</creatorcontrib><creatorcontrib>Boersma, Eric, PhD</creatorcontrib><creatorcontrib>Vidakovic, Radosav, MD</creatorcontrib><creatorcontrib>van Sambeek, Marc R.H.M., MD</creatorcontrib><creatorcontrib>Noordzij, Peter G., MD</creatorcontrib><creatorcontrib>Bax, Jeroen J., MD</creatorcontrib><creatorcontrib>Poldermans, Don, MD</creatorcontrib><title>Intensity of Statin Therapy in Relation to Myocardial Ischemia, Troponin T Release, and Clinical Cardiac Outcome in Patients Undergoing Major Vascular Surgery</title><title>Journal of the American College of Cardiology</title><addtitle>J Am Coll Cardiol</addtitle><description>Intensity of Statin Therapy in Relation to Myocardial Ischemia, Troponin T Release, and Clinical Cardiac Outcome in Patients Undergoing Major Vascular Surgery Harm H. H. Feringa, Olaf Schouten, Stefanos E. Karagiannis, Jasper Brugts, Abdou Elhendy, Eric Boersma, Radosav Vidakovic, Marc R.H.M. van Sambeek, Peter G. Noordzij, Jeroen J. Bax, Don Poldermans The cardioprotective effects of statins in patients undergoing major vascular surgery remain not well defined. In a prospective study of 359 patients, statin dose and cholesterol levels were recorded before major vascular surgery. In multivariate analysis, lower low-density lipoprotein cholesterol correlated with lower myocardial ischemia, troponin T release, and 30-day and late cardiac events. Higher statin doses (expressed as percentage of maximum recommended therapeutic dose) correlated with lower myocardial ischemia, troponin T release, and 30-day and late cardiac events, even after adjusting for low-density lipoprotein cholesterol. Significantly higher perioperative heart rate variability was observed in patients with higher statin doses.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - metabolism</subject><subject>Cardiology</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular</subject><subject>Cholesterol</subject><subject>Cholesterol, LDL - drug effects</subject><subject>Cholesterol, LDL - metabolism</subject><subject>Coronary heart disease</subject><subject>Dose-Response Relationship, Drug</subject><subject>Female</subject><subject>Heart</subject><subject>Heart attacks</subject><subject>Heart Rate - drug effects</subject><subject>Humans</subject><subject>Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage</subject><subject>Internal Medicine</subject><subject>Low density lipoprotein</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Multivariate Analysis</subject><subject>Myocardial Ischemia - diagnosis</subject><subject>Myocardial Ischemia - metabolism</subject><subject>Myocarditis. Cardiomyopathies</subject><subject>Outcome Assessment (Health Care)</subject><subject>Prospective Studies</subject><subject>Statins</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Troponin T - drug effects</subject><subject>Troponin T - secretion</subject><subject>Vascular surgery: aorta, extremities, vena cava. Surgery of the lymphatic vessels</subject><subject>Vascular Surgical Procedures</subject><issn>0735-1097</issn><issn>1558-3597</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kl-LEzEUxQdR3Lr6BXyQgOjTtt5MZpIJiCDFP4VdVmzX15DJ3HYzTpOazAjzZfysZmyhsA8-JYTfOdycc7PsJYUFBcrftYtWG7PIAcQC-AIK_iib0bKs5qyU4nE2A8HKOQUpLrJnMbYAwCsqn2YXVMgSaMFn2Z-V69FF24_Eb8m61711ZHOPQR9Gkq7fsUtP3pHek5vRGx0aqzuyiuYe91ZfkU3wB-8m0cSijnhFtGvIsrPOmoQu_0kMuR164_c4mX5Lluj6SO5cg2HnrduRG936QH7oaIZOB7Iewg7D-Dx7stVdxBen8zK7-_xps_w6v779slp-vJ6bElg_L6TcIvIml9iAKLecNw0VnNW6pgw1SGRFgbSQTV0ZxjTPa1E0QGsGYApB2WX29uh7CP7XgLFXexsNdp126IeoeFVQLlmVwNcPwNYPwaXZFC2BU1lSyhKVHykTfIwBt-oQ7F6HUVFQU3eqVVN3aupOAVepuyR6dbIe6j02Z8mprAS8OQEpJd1tg3bGxjMnqSgqPs34_shhSuy3xaCiSXkbbGxA06vG2__P8eGB3Jy6_IkjxvN_VcwVqPW0ZdOSgYCcyUKwv4ZnzSo</recordid><startdate>20071023</startdate><enddate>20071023</enddate><creator>Feringa, Harm H.H., MD</creator><creator>Schouten, Olaf, MD</creator><creator>Karagiannis, Stefanos E., MD</creator><creator>Brugts, Jasper, MD</creator><creator>Elhendy, Abdou, MD</creator><creator>Boersma, Eric, PhD</creator><creator>Vidakovic, Radosav, MD</creator><creator>van Sambeek, Marc R.H.M., MD</creator><creator>Noordzij, Peter G., MD</creator><creator>Bax, Jeroen J., MD</creator><creator>Poldermans, Don, MD</creator><general>Elsevier Inc</general><general>Elsevier Science</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20071023</creationdate><title>Intensity of Statin Therapy in Relation to Myocardial Ischemia, Troponin T Release, and Clinical Cardiac Outcome in Patients Undergoing Major Vascular Surgery</title><author>Feringa, Harm H.H., MD ; Schouten, Olaf, MD ; Karagiannis, Stefanos E., MD ; Brugts, Jasper, MD ; Elhendy, Abdou, MD ; Boersma, Eric, PhD ; Vidakovic, Radosav, MD ; van Sambeek, Marc R.H.M., MD ; Noordzij, Peter G., MD ; Bax, Jeroen J., MD ; Poldermans, Don, MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c503t-499fee6d29ed075f66dd1763bab13ea09e344e149db8c33a62b74d01b300c4713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - metabolism</topic><topic>Cardiology</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular</topic><topic>Cholesterol</topic><topic>Cholesterol, LDL - drug effects</topic><topic>Cholesterol, LDL - metabolism</topic><topic>Coronary heart disease</topic><topic>Dose-Response Relationship, Drug</topic><topic>Female</topic><topic>Heart</topic><topic>Heart attacks</topic><topic>Heart Rate - drug effects</topic><topic>Humans</topic><topic>Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage</topic><topic>Internal Medicine</topic><topic>Low density lipoprotein</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Multivariate Analysis</topic><topic>Myocardial Ischemia - diagnosis</topic><topic>Myocardial Ischemia - metabolism</topic><topic>Myocarditis. Cardiomyopathies</topic><topic>Outcome Assessment (Health Care)</topic><topic>Prospective Studies</topic><topic>Statins</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Troponin T - drug effects</topic><topic>Troponin T - secretion</topic><topic>Vascular surgery: aorta, extremities, vena cava. 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H. Feringa, Olaf Schouten, Stefanos E. Karagiannis, Jasper Brugts, Abdou Elhendy, Eric Boersma, Radosav Vidakovic, Marc R.H.M. van Sambeek, Peter G. Noordzij, Jeroen J. Bax, Don Poldermans The cardioprotective effects of statins in patients undergoing major vascular surgery remain not well defined. In a prospective study of 359 patients, statin dose and cholesterol levels were recorded before major vascular surgery. In multivariate analysis, lower low-density lipoprotein cholesterol correlated with lower myocardial ischemia, troponin T release, and 30-day and late cardiac events. Higher statin doses (expressed as percentage of maximum recommended therapeutic dose) correlated with lower myocardial ischemia, troponin T release, and 30-day and late cardiac events, even after adjusting for low-density lipoprotein cholesterol. Significantly higher perioperative heart rate variability was observed in patients with higher statin doses.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>17950146</pmid><doi>10.1016/j.jacc.2007.06.046</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Biological and medical sciences Biomarkers - metabolism Cardiology Cardiology. Vascular system Cardiovascular Cholesterol Cholesterol, LDL - drug effects Cholesterol, LDL - metabolism Coronary heart disease Dose-Response Relationship, Drug Female Heart Heart attacks Heart Rate - drug effects Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage Internal Medicine Low density lipoprotein Male Medical sciences Multivariate Analysis Myocardial Ischemia - diagnosis Myocardial Ischemia - metabolism Myocarditis. Cardiomyopathies Outcome Assessment (Health Care) Prospective Studies Statins Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Troponin T - drug effects Troponin T - secretion Vascular surgery: aorta, extremities, vena cava. Surgery of the lymphatic vessels Vascular Surgical Procedures |
| title | Intensity of Statin Therapy in Relation to Myocardial Ischemia, Troponin T Release, and Clinical Cardiac Outcome in Patients Undergoing Major Vascular Surgery |
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