Intensity of Statin Therapy in Relation to Myocardial Ischemia, Troponin T Release, and Clinical Cardiac Outcome in Patients Undergoing Major Vascular Surgery

Intensity of Statin Therapy in Relation to Myocardial Ischemia, Troponin T Release, and Clinical Cardiac Outcome in Patients Undergoing Major Vascular Surgery Harm H. H. Feringa, Olaf Schouten, Stefanos E. Karagiannis, Jasper Brugts, Abdou Elhendy, Eric Boersma, Radosav Vidakovic, Marc R.H.M. van Sa...

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Veröffentlicht in:	Journal of the American College of Cardiology 2007-10, Vol.50 (17), p.1649-1656
Hauptverfasser:	Feringa, Harm H.H., MD, Schouten, Olaf, MD, Karagiannis, Stefanos E., MD, Brugts, Jasper, MD, Elhendy, Abdou, MD, Boersma, Eric, PhD, Vidakovic, Radosav, MD, van Sambeek, Marc R.H.M., MD, Noordzij, Peter G., MD, Bax, Jeroen J., MD, Poldermans, Don, MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Biological and medical sciences Biomarkers - metabolism Cardiology Cardiology. Vascular system Cardiovascular Cholesterol Cholesterol, LDL - drug effects Cholesterol, LDL - metabolism Coronary heart disease Dose-Response Relationship, Drug Female Heart Heart attacks Heart Rate - drug effects Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage Internal Medicine Low density lipoprotein Male Medical sciences Multivariate Analysis Myocardial Ischemia - diagnosis Myocardial Ischemia - metabolism Myocarditis. Cardiomyopathies Outcome Assessment (Health Care) Prospective Studies Statins Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Troponin T - drug effects Troponin T - secretion Vascular surgery: aorta, extremities, vena cava. Surgery of the lymphatic vessels Vascular Surgical Procedures
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Zusammenfassung:	Intensity of Statin Therapy in Relation to Myocardial Ischemia, Troponin T Release, and Clinical Cardiac Outcome in Patients Undergoing Major Vascular Surgery Harm H. H. Feringa, Olaf Schouten, Stefanos E. Karagiannis, Jasper Brugts, Abdou Elhendy, Eric Boersma, Radosav Vidakovic, Marc R.H.M. van Sambeek, Peter G. Noordzij, Jeroen J. Bax, Don Poldermans The cardioprotective effects of statins in patients undergoing major vascular surgery remain not well defined. In a prospective study of 359 patients, statin dose and cholesterol levels were recorded before major vascular surgery. In multivariate analysis, lower low-density lipoprotein cholesterol correlated with lower myocardial ischemia, troponin T release, and 30-day and late cardiac events. Higher statin doses (expressed as percentage of maximum recommended therapeutic dose) correlated with lower myocardial ischemia, troponin T release, and 30-day and late cardiac events, even after adjusting for low-density lipoprotein cholesterol. Significantly higher perioperative heart rate variability was observed in patients with higher statin doses.
ISSN:	0735-1097 1558-3597
DOI:	10.1016/j.jacc.2007.06.046