VEGF-D in association with VEGFR-3 promotes nodal metastasis in human invasive lobular breast cancer

We assessed the expression of vascular endothelial growth factors (VEGF-C and VEGF-D) in breast cancer cells and the density of lymph vessels and VEGF receptor-3 (VEGFR-3)-positive vessels in and around the tumor in invasive lobular breast cancer. We found significant correlation between peritumoral...

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Veröffentlicht in:	American journal of clinical pathology 2007-11, Vol.128 (5), p.759-766
Hauptverfasser:	VAN ITERSON, Vincent, LEIDENIUS, Marjut, VON SMITTEN, Karl, BONO, Petri, HEIKKILÄ, Päivi
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Biomarkers, Tumor - metabolism Breast Neoplasms - blood supply Breast Neoplasms - metabolism Breast Neoplasms - pathology Carcinoma, Lobular - blood supply Carcinoma, Lobular - metabolism Carcinoma, Lobular - secondary Endothelial Cells - metabolism Endothelial Cells - pathology Female Hematologic and hematopoietic diseases Humans Investigative techniques, diagnostic techniques (general aspects) Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymph Nodes - pathology Lymphatic Metastasis Medical sciences Middle Aged Neoplasm Proteins - metabolism Neoplasm Staging Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Vascular Endothelial Growth Factor D - metabolism Vascular Endothelial Growth Factor Receptor-3 - metabolism
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Zusammenfassung:	We assessed the expression of vascular endothelial growth factors (VEGF-C and VEGF-D) in breast cancer cells and the density of lymph vessels and VEGF receptor-3 (VEGFR-3)-positive vessels in and around the tumor in invasive lobular breast cancer. We found significant correlation between peritumoral lymph vessel density and presence of lymph node metastases (P=.001) and the number of metastatic lymph nodes (P
ISSN:	0002-9173 1943-7722
DOI:	10.1309/7FXVRMXF58PVRJUH