A prospective study on the prevalence and risk factors for neonatal thrombocytopenia and platelet alloimmunization among 9332 unselected Brazilian newborns

BACKGROUND: Neonatal thrombocytopenia (NT) occurs in 0.5 to 0.9% of unselected Caucasian newborns. However, the prevalence of this complication in other populations is unknown. In this study the prevalence/causes of NT was determined in Brazilian newborns, a population characterized by admixture amo...

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Veröffentlicht in:	Transfusion (Philadelphia, Pa.) Pa.), 2007-01, Vol.47 (1), p.59-66
Hauptverfasser:	Castro, Vagner, Kroll, Hartmut, Origa, Andréa F., Falconi, Mônica A., Marques, Sílvia B.D., Marba, Sérgio T., Passini Jr, Renato, Annichino-Bizzacchi, Joyce M., Costa, Fernando F., Santoso, Sentot, Arruda, Valder R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Antibodies - blood Antigens, Human Platelet - genetics Biological and medical sciences Blood and lymphatic vessels Blood coagulation. Blood cells Blood Platelets - immunology Blood Platelets - pathology Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis Brazil - epidemiology Cardiology. Vascular system Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Female Fundamental and applied biological sciences. Psychology Genotype HLA Antigens - immunology Humans Infant, Newborn Isoantibodies - blood Medical sciences Middle Aged Molecular and cellular biology Mothers Platelet Platelet Count Prevalence Prospective Studies Risk Factors Thrombocytopenia - blood Thrombocytopenia - congenital Thrombocytopenia - epidemiology Thrombocytopenia - immunology Transfusions. Complications. Transfusion reactions. Cell and gene therapy
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Zusammenfassung:	BACKGROUND: Neonatal thrombocytopenia (NT) occurs in 0.5 to 0.9% of unselected Caucasian newborns. However, the prevalence of this complication in other populations is unknown. In this study the prevalence/causes of NT was determined in Brazilian newborns, a population characterized by admixture among Indigenous, Africans, and Caucasians. STUDY DESIGN: A prospective study was carried out in a 3‐year period, to determine the prevalence and causes of thrombocytopenia in cord blood samples. Genotyping for HPA 1‐5 systems was performed in pairs of mother/neonates with and without thrombocytopenia. All mothers with genotypic mismatches from each group were tested for HPA‐specific antibody using the MAIPA technique to identify alloimmunization. RESULTS: Platelet counts
ISSN:	0041-1132 1537-2995
DOI:	10.1111/j.1537-2995.2007.01064.x