Multicomponent Radical Processes: Synthesis of Substituted Piperidinones
Three and four-component radical and radical−organometallic processes have been developed that provide a simple access to 2,3-disubstituted piperidinones. Reasonable yield and high stereoselectivities were achieved in a number of cases with three C−C bonds and one C−N bond and up to three stereogeni...
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Veröffentlicht in: | Journal of the American Chemical Society 2007-10, Vol.129 (42), p.12662-12663 |
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Hauptverfasser: | , |
Format: | Artikel |
Sprache: | eng |
Online-Zugang: | Volltext |
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Zusammenfassung: | Three and four-component radical and radical−organometallic processes have been developed that provide a simple access to 2,3-disubstituted piperidinones. Reasonable yield and high stereoselectivities were achieved in a number of cases with three C−C bonds and one C−N bond and up to three stereogenic centers generated in one pot from readily available reagents. |
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ISSN: | 0002-7863 1520-5126 |
DOI: | 10.1021/ja075755l |