Multicomponent Radical Processes:  Synthesis of Substituted Piperidinones

Three and four-component radical and radical−organometallic processes have been developed that provide a simple access to 2,3-disubstituted piperidinones. Reasonable yield and high stereoselectivities were achieved in a number of cases with three C−C bonds and one C−N bond and up to three stereogeni...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of the American Chemical Society 2007-10, Vol.129 (42), p.12662-12663
Hauptverfasser: Godineau, Edouard, Landais, Yannick
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Three and four-component radical and radical−organometallic processes have been developed that provide a simple access to 2,3-disubstituted piperidinones. Reasonable yield and high stereoselectivities were achieved in a number of cases with three C−C bonds and one C−N bond and up to three stereogenic centers generated in one pot from readily available reagents.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja075755l