Interleukin-7 induced facilitation of immunological reconstitution of sublethally irradiated mice following treatment with alloreactive spleen cells in a murine model of B-cell leukemia lymphoma (BCL )

Interleukin-7 induced facilitation of immunological reconstitution of sublethally irradiated mice following treatment with alloreactive spleen cells in a murine model of B-cell leukemia lymphoma (BCL )

Interleukin-7 (IL-7) plays a key role in maturation and function of both T and B cells. We investigate the potential use of recombinant human IL-7 for facilitation of graft-versus-leukemia (GVL) effects mediated by T cells following transplantation in a murine model. Administration of IL-7 in vivo t...

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Veröffentlicht in:Bone marrow transplantation (Basingstoke) 2007-11, Vol.40 (9), p.881-889
Hauptverfasser: ABDUL-HAI, A, WEISS, L, BEN-YEHUDA, A, ERGAS, D, SHAPIRA, M. Y, SLAVIN, S
Format: Artikel
Sprache:eng
Schlagworte:
Adoptive Transfer
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Animal models
Animals
Biological and medical sciences
Bone marrow
Bone marrow, stem cells transplantation. Graft versus host reaction
Care and treatment
Cell Transplantation - methods
Cytokines
Diagnosis
Disease Models, Animal
Disease-Free Survival
Graft vs Leukemia Effect - drug effects
Health aspects
Hematologic and hematopoietic diseases
Humans
Immune reconstitution
Immune System - physiology
Immunology
Interleukin 7
Interleukin-7 - pharmacology
Interleukin-7 - therapeutic use
Interleukins
Leukemia
Leukemia, B-Cell - therapy
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Lymphocytes
Lymphocytes B
Lymphocytes T
Lymphocytic leukemia
Lymphoma
Lymphoma, B-Cell - therapy
Medical sciences
Methods
Mice
Mice, Inbred Strains
Physiological aspects
Regeneration - drug effects
Spleen
Spleen - cytology
Stem cell transplantation
Stem cells
Thymus
Transfusions. Complications. Transfusion reactions. Cell and gene therapy
Transplantation
Transplantation, Homologous
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Zusammenfassung:Interleukin-7 (IL-7) plays a key role in maturation and function of both T and B cells. We investigate the potential use of recombinant human IL-7 for facilitation of graft-versus-leukemia (GVL) effects mediated by T cells following transplantation in a murine model. Administration of IL-7 in vivo to allogeneic-transplanted mice improved disease-free survival: 67% of mice treated with IL-7 remained alive and disease free for more than 60 days, in comparison to 17% of the controls (P
ISSN:0268-3369
1476-5365
DOI:10.1038/sj.bmt.1705819