Altered Intestinal Function in Patients With Chronic Heart Failure

Altered Intestinal Function in Patients With Chronic Heart Failure Anja Sandek, Juergen Bauditz, Alexander Swidsinski, Sabine Buhner, Jutta Weber-Eibel, Stephan von Haehling, Wieland Schroedl, Tim Karhausen, Wolfram Doehner, Mathias Rauchhaus, Philip Poole-Wilson, Hans-Dieter Volk, Herbert Lochs, St...

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Veröffentlicht in:	Journal of the American College of Cardiology 2007-10, Vol.50 (16), p.1561-1569
Hauptverfasser:	Sandek, Anja, MD, Bauditz, Juergen, MD, Swidsinski, Alexander, MD, Buhner, Sabine, PhD, Weber-Eibel, Jutta, MD, von Haehling, Stephan, MD, Schroedl, Wieland, Karhausen, Tim, Doehner, Wolfram, MD, PhD, Rauchhaus, Mathias, MD, PhD, Poole-Wilson, Philip, MD, FMedSci, Volk, Hans-Dieter, MD, PhD, Lochs, Herbert, MD, PhD, Anker, Stefan D., MD, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Bacteria Biofilms Biological and medical sciences Cardiology Cardiology. Vascular system Cardiovascular Case-Control Studies Disease Drug therapy Enzymes Female Gastrointestinal Agents - pharmacokinetics Heart Heart failure Heart Failure - complications Heart failure, cardiogenic pulmonary edema, cardiac enlargement Humans Immunoglobulin A - immunology Internal Medicine Intestinal Absorption - physiology Intestinal Mucosa - microbiology Intestines - blood supply Intestines - diagnostic imaging Ischemia - complications Lactulose - pharmacokinetics Leukocytes - metabolism Lipopolysaccharides - immunology Liver cirrhosis Male Mannitol - pharmacokinetics Medical sciences Middle Aged Mortality Permeability Rodents Small intestine Sucrose - analogs & derivatives Sucrose - pharmacokinetics Sweetening Agents - pharmacokinetics Tumor Necrosis Factor-alpha - blood Ultrasonography Xylose - pharmacokinetics
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Zusammenfassung:	Altered Intestinal Function in Patients With Chronic Heart Failure Anja Sandek, Juergen Bauditz, Alexander Swidsinski, Sabine Buhner, Jutta Weber-Eibel, Stephan von Haehling, Wieland Schroedl, Tim Karhausen, Wolfram Doehner, Mathias Rauchhaus, Philip Poole-Wilson, Hans-Dieter Volk, Herbert Lochs, Stefan D. Anker Intestinal translocation of bacterial endotoxin may contribute to the inflammatory state observed in patients with chronic heart failure (CHF). Twenty-two CHF patients compared with 22 control subjects had an increase of bowel wall thickness in the terminal ileum, ascending colon, transverse colon, descending colon, and sigmoid. Small and large permeability was increased, and D-xylose absorption was decreased, indicating bowel ischemia. Higher concentrations of adherent bacteria were found within mucus of patients compared with control subjects. These changes may contribute to both chronic inflammation and malnutrition. Chronic heart failure is a multisystem disorder associated with alteration of intestinal function.
ISSN:	0735-1097 1558-3597
DOI:	10.1016/j.jacc.2007.07.016