Something is better than nothing

According to two researchers in the area, "many of us in the academic community have inadvertently participated in the limitation of a generation of research on bipolar illness ... by demands for methodological purity or study comprehensiveness that can rarely be achieved" ([1], p. 17). The panel proudly points to the fact that, even though folate was well known to decrease the risk of neural tube defects in animal studies, policy recommendations for folate supplementation to prevent neural tube defects were delayed while authorities waited some years for confirmation from RCTs.