Effects of Anemarrhena asphodeloides on Focal Ischemic Brain Injury Induced by Middle Cerebral Artery Occlusion in Rats

The preventive effect of Anemarrhena asphodeloides BUNGE (Liliaceae), a traditional Chinese medicine, on ischemia-reperfusion-induced brain injury was evaluated in the rat brain. Ischemia was induced by intraluminal occlusion of the right middle cerebral artery for 2 h and reperfusion was continued...

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Veröffentlicht in:	Biological & Pharmaceutical Bulletin 2007, Vol.30(1), pp.38-43
Hauptverfasser:	Oh, Jin Kyung, Hyun, Seung Ye, Oh, Hye Rim, Jung, Ji Wook, Park, Chan, Lee, Sun-Young, Park, Ji Ho, Kim, Sun Yeou, Kim, Ki Hoon, Kim, Young Kyun, Ryu, Jong Hoon
Format:	Artikel
Sprache:	eng
Schlagworte:	Anemarrhena Anemarrhena asphodeloides Animals Biphenyl Compounds - chemistry Brain - drug effects Brain - metabolism Brain - pathology Disease Models, Animal Dose-Response Relationship, Drug Drugs, Chinese Herbal - chemistry Drugs, Chinese Herbal - pharmacology Drugs, Chinese Herbal - therapeutic use Free Radical Scavengers - chemistry Free Radical Scavengers - pharmacology Free Radical Scavengers - therapeutic use Hydrazines - chemistry Immunohistochemistry Infarction, Middle Cerebral Artery - complications ischemia-reperfusion Ischemic Attack, Transient - drug therapy Ischemic Attack, Transient - etiology Ischemic Attack, Transient - metabolism Ischemic Attack, Transient - pathology Liliaceae Male myeloperoxidase (MPO) Neuroprotective Agents - chemistry Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use neutrophil Neutrophil Infiltration - drug effects Peroxidase - metabolism Picrates Rats Rats, Sprague-Dawley Reperfusion Injury - etiology Reperfusion Injury - metabolism Reperfusion Injury - pathology Reperfusion Injury - prevention & control Rhizome Saponins - analysis Time Factors Triterpenes - analysis
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Zusammenfassung:	The preventive effect of Anemarrhena asphodeloides BUNGE (Liliaceae), a traditional Chinese medicine, on ischemia-reperfusion-induced brain injury was evaluated in the rat brain. Ischemia was induced by intraluminal occlusion of the right middle cerebral artery for 2 h and reperfusion was continued for 22 h. Water extract of Anemarrhena asphodeloides (WEAA) was orally administered promptly prior to and 2 h after reperfusion. Total infarct volume and edema in the ipsilateral hemispheres of ischemia-reperfusion rats were significantly reduced by treatment with WEAA in a dose-dependent manner (p
ISSN:	0918-6158 1347-5215
DOI:	10.1248/bpb.30.38