Controversies and Challenges in Defining the Etiology and Pathophysiology of Restless Legs Syndrome

Controversies and Challenges in Defining the Etiology and Pathophysiology of Restless Legs Syndrome

Abstract Restless legs syndrome (RLS) can occur as a primary disorder, with no apparent cause other than a possible genetic predisposition, or as a secondary condition, most commonly related to iron deficiency, pregnancy, or end-stage renal disease. Recent studies have identified 2 different phenoty...

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Veröffentlicht in:The American journal of medicine 2007, Vol.120 (1), p.S13-S21
1. Verfasser: Allen, Richard P., PhD
Format: Artikel
Sprache:eng
Schlagworte:
Central Nervous System - physiopathology
Dopamine
Dopamine - physiology
Epidemiology
Humans
Internal Medicine
Iron
Iron - deficiency
Iron - physiology
Medical diagnosis
Pathology
Phenotype
Prevalence
Restless Legs Syndrome
Restless Legs Syndrome - epidemiology
Restless Legs Syndrome - etiology
Restless Legs Syndrome - physiopathology
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Beschreibung
Zusammenfassung:Abstract Restless legs syndrome (RLS) can occur as a primary disorder, with no apparent cause other than a possible genetic predisposition, or as a secondary condition, most commonly related to iron deficiency, pregnancy, or end-stage renal disease. Recent studies have identified 2 different phenotypes of RLS based on age at onset of symptoms. Persons whose RLS symptoms start at an earlier age (
ISSN:0002-9343
1555-7162
DOI:10.1016/j.amjmed.2006.11.003