Recent developments in methods and technology for analysis of biological samples by MALDI-TOF-MS

Recent developments in methods and technology for analysis of biological samples by MALDI-TOF-MS

Matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry (MALDI-TOF-MS) is widely used in a variety of fields because it has the characteristics of speed, ease of use, high sensitivity, and wide detectable mass range for obtaining molecular weights and for structural characteriza...

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Veröffentlicht in:Analytical and bioanalytical chemistry 2007-01, Vol.387 (1), p.193-204
Hauptverfasser: Pan, Chensong, Xu, Songyun, Zhou, Houjiang, Fu, Yu, Ye, Mingliang, Zou, Hanfa
Format: Artikel
Sprache:eng
Schlagworte:
Additives
Analytic Sample Preparation Methods - instrumentation
Analytic Sample Preparation Methods - methods
Analytic Sample Preparation Methods - trends
Arginine - analogs & derivatives
Arginine - analysis
Biological analysis
Biological properties
Biological samples
Ionization
Ions
Macromolecules
MALDI
Mass spectrometry
Mass spectroscopy
Matrix
Nanomaterials
Nanostructures - chemistry
Nanotechnology
Oligodeoxyribonucleotides - analysis
Proteins - analysis
Review
Sample pretreatment
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - instrumentation
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - trends
Structural analysis
Technology assessment
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Beschreibung
Zusammenfassung:Matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry (MALDI-TOF-MS) is widely used in a variety of fields because it has the characteristics of speed, ease of use, high sensitivity, and wide detectable mass range for obtaining molecular weights and for structural characterization of macromolecules. In this article we summarize recent developments in matrix additives, new matrices, and sample-pretreatment methods using off-probe or on-probe techniques or nanomaterials for MALDI-TOF-MS analysis of biological samples.
ISSN:1618-2642
1618-2650
DOI:10.1007/s00216-006-0905-4