Enhanced Plasma Soluble CD40 Ligand Levels in Essential Hypertensive Patients With Blunted Nocturnal Blood Pressure Decrease
Hypertensives with a blunted nocturnal blood pressure (BP) decrease have increased risk of developing atherosclerotic disease. Soluble CD40 ligand (sCD40L) is involved in the pathogenesis of risk factor-related vascular damage. Therefore, we evaluated the relationship between circulating sCD40L leve...
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| creator | Desideri, Giovambattista Cipollone, Francesco Valeri, Letizia Grassi, Davide Necozione, Stefano Croce, Giuseppe Passacquale, Gabriella Garofalo, Angela Lippi, Cristina Mezzetti, Andrea Ferri, Claudio |
| description | Hypertensives with a blunted nocturnal blood pressure (BP) decrease have increased risk of developing atherosclerotic disease. Soluble CD40 ligand (sCD40L) is involved in the pathogenesis of risk factor-related vascular damage. Therefore, we evaluated the relationship between circulating sCD40L levels, circadian BP profile, and early carotid atherosclerosis in essential hypertensives.
Plasma sCD40L concentrations were assessed in two groups of 25 never-treated hypertensives, without additional cardiovascular risk factors, differentiated on the basis of a nocturnal decrease of BP either of >10% (dippers) or |
| doi_str_mv | 10.1016/j.amjhyper.2006.06.007 |
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Plasma sCD40L concentrations were assessed in two groups of 25 never-treated hypertensives, without additional cardiovascular risk factors, differentiated on the basis of a nocturnal decrease of BP either of >10% (dippers) or <10% (nondippers) of daytime values, and in 25 matched normotensives. Carotid intima–media thickness (IMT) was also measured in all participants.
Plasma sCD40L concentrations were higher in nondippers (4.9 ± 1.2 ng/mL) than in dippers (3.7 ± 0.7,
P = .0005) and controls (1.6 ± 0.6,
P < .0001). These latter had lower sCD40L concentrations than dippers (
P < .0001). The IMT was higher in both hypertensive groups than in normotensives (
P < .0001). In the entire hypertensive population IMT directly correlated with circulating levels of sCD40L (
r = 0.365,
P = .01) and inversely correlated with nocturnal systolic BP decreases (
r = −0.286,
P = .043). In a multivariate regression analysis sCD40L was the main determinant of IMT (
r
2 = 0.157,
P = .004).
Nondippers have enhanced plasma sCD40L levels, which may contribute to their increased susceptibility to develop vascular damage.</description><identifier>ISSN: 0895-7061</identifier><identifier>EISSN: 1879-1905</identifier><identifier>EISSN: 1941-7225</identifier><identifier>DOI: 10.1016/j.amjhyper.2006.06.007</identifier><identifier>PMID: 17198914</identifier><identifier>CODEN: AJHYE6</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Arterial hypertension. Arterial hypotension ; atherosclerosis ; Biological and medical sciences ; Blood and lymphatic vessels ; Blood Pressure - physiology ; blood pressure measurement/monitoring ; C-Reactive Protein - metabolism ; Cardiology. Vascular system ; Carotid Artery, Common - pathology ; CD40 Ligand - blood ; CD40L ; Circadian Rhythm - physiology ; Clinical manifestations. Epidemiology. Investigative techniques. Etiology ; Experimental diseases ; Humans ; hypertension ; Hypertension - blood ; Hypertension - pathology ; Hypertension - physiopathology ; isoprostanes ; Isoprostanes - blood ; Medical sciences ; Middle Aged ; Platelet Activation - physiology</subject><ispartof>American journal of hypertension, 2007, Vol.20 (1), p.70-76</ispartof><rights>2007 American Journal of Hypertension, Ltd.</rights><rights>2007 INIST-CNRS</rights><rights>Copyright Nature Publishing Group Jan 2007</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c487t-b183d3966fb9ed4df5787030ea1c790c9b43019ad42ebdea24f7104c01a8f0d33</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4022,27922,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18488310$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17198914$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Desideri, Giovambattista</creatorcontrib><creatorcontrib>Cipollone, Francesco</creatorcontrib><creatorcontrib>Valeri, Letizia</creatorcontrib><creatorcontrib>Grassi, Davide</creatorcontrib><creatorcontrib>Necozione, Stefano</creatorcontrib><creatorcontrib>Croce, Giuseppe</creatorcontrib><creatorcontrib>Passacquale, Gabriella</creatorcontrib><creatorcontrib>Garofalo, Angela</creatorcontrib><creatorcontrib>Lippi, Cristina</creatorcontrib><creatorcontrib>Mezzetti, Andrea</creatorcontrib><creatorcontrib>Ferri, Claudio</creatorcontrib><title>Enhanced Plasma Soluble CD40 Ligand Levels in Essential Hypertensive Patients With Blunted Nocturnal Blood Pressure Decrease</title><title>American journal of hypertension</title><addtitle>AJH</addtitle><description>Hypertensives with a blunted nocturnal blood pressure (BP) decrease have increased risk of developing atherosclerotic disease. Soluble CD40 ligand (sCD40L) is involved in the pathogenesis of risk factor-related vascular damage. Therefore, we evaluated the relationship between circulating sCD40L levels, circadian BP profile, and early carotid atherosclerosis in essential hypertensives.
Plasma sCD40L concentrations were assessed in two groups of 25 never-treated hypertensives, without additional cardiovascular risk factors, differentiated on the basis of a nocturnal decrease of BP either of >10% (dippers) or <10% (nondippers) of daytime values, and in 25 matched normotensives. Carotid intima–media thickness (IMT) was also measured in all participants.
Plasma sCD40L concentrations were higher in nondippers (4.9 ± 1.2 ng/mL) than in dippers (3.7 ± 0.7,
P = .0005) and controls (1.6 ± 0.6,
P < .0001). These latter had lower sCD40L concentrations than dippers (
P < .0001). The IMT was higher in both hypertensive groups than in normotensives (
P < .0001). In the entire hypertensive population IMT directly correlated with circulating levels of sCD40L (
r = 0.365,
P = .01) and inversely correlated with nocturnal systolic BP decreases (
r = −0.286,
P = .043). In a multivariate regression analysis sCD40L was the main determinant of IMT (
r
2 = 0.157,
P = .004).
Nondippers have enhanced plasma sCD40L levels, which may contribute to their increased susceptibility to develop vascular damage.</description><subject>Arterial hypertension. Arterial hypotension</subject><subject>atherosclerosis</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Blood Pressure - physiology</subject><subject>blood pressure measurement/monitoring</subject><subject>C-Reactive Protein - metabolism</subject><subject>Cardiology. Vascular system</subject><subject>Carotid Artery, Common - pathology</subject><subject>CD40 Ligand - blood</subject><subject>CD40L</subject><subject>Circadian Rhythm - physiology</subject><subject>Clinical manifestations. Epidemiology. Investigative techniques. Etiology</subject><subject>Experimental diseases</subject><subject>Humans</subject><subject>hypertension</subject><subject>Hypertension - blood</subject><subject>Hypertension - pathology</subject><subject>Hypertension - physiopathology</subject><subject>isoprostanes</subject><subject>Isoprostanes - blood</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Platelet Activation - physiology</subject><issn>0895-7061</issn><issn>1879-1905</issn><issn>1941-7225</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqF0lGr0zAUB_Aiinde_QqXgHjfOk_WNEnf9G7TKWNeUFF8CWl66lKzdibt8IIf3tRNB74IgUD45Zwk_yTJFYUpBcqfN1O9a7Z3e_TTGQCfjgPEvWRCpShSWkB-P5mALPJUAKcXyaMQGgBgnNOHyQUVtJAFZZPk57Ld6tZgRW6dDjtN3nduKB2S-YIBWduvuq3IGg_oArEtWYaAbW-1I6uxd49tsAckt7q3cT2QT7bfkhs3tH2suOlMP_g24hvXdbGDxxAGj2SBxqMO-Dh5UGsX8Mlpvkw-vlp-mK_S9bvXb-Yv16lhUvRpSWVWZQXndVlgxao6F1JABqipEQWYomQZ0EJXbIZlhXrGakGBGaBa1lBl2WVyfay79933AUOvdjYYdE632A1BcZlJmjMR4dN_YNP9vkFQFGa5yGk2K6LiR2V8F4LHWu293Wl_F5Ea01GN-pOOGtNR44Cx_NWp_FDusDpvO8URwbMT0MFoV_sYjQ1nJ5mUGYXoyNG1Or4w_gW62cZ-glIaSXokNvT44yz8N8VFJnK1-vxFcVjkG_4W1Cb6F0cfk8aDjScPJmYaf4b1aHpVdfZ_1_sF1NLLIw</recordid><startdate>2007</startdate><enddate>2007</enddate><creator>Desideri, Giovambattista</creator><creator>Cipollone, Francesco</creator><creator>Valeri, Letizia</creator><creator>Grassi, Davide</creator><creator>Necozione, Stefano</creator><creator>Croce, Giuseppe</creator><creator>Passacquale, Gabriella</creator><creator>Garofalo, Angela</creator><creator>Lippi, Cristina</creator><creator>Mezzetti, Andrea</creator><creator>Ferri, Claudio</creator><general>Elsevier Inc</general><general>Oxford University Press</general><general>Elsevier Science</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>2007</creationdate><title>Enhanced Plasma Soluble CD40 Ligand Levels in Essential Hypertensive Patients With Blunted Nocturnal Blood Pressure Decrease</title><author>Desideri, Giovambattista ; Cipollone, Francesco ; Valeri, Letizia ; Grassi, Davide ; Necozione, Stefano ; Croce, Giuseppe ; Passacquale, Gabriella ; Garofalo, Angela ; Lippi, Cristina ; Mezzetti, Andrea ; Ferri, Claudio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c487t-b183d3966fb9ed4df5787030ea1c790c9b43019ad42ebdea24f7104c01a8f0d33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Arterial hypertension. Arterial hypotension</topic><topic>atherosclerosis</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Blood Pressure - physiology</topic><topic>blood pressure measurement/monitoring</topic><topic>C-Reactive Protein - metabolism</topic><topic>Cardiology. Vascular system</topic><topic>Carotid Artery, Common - pathology</topic><topic>CD40 Ligand - blood</topic><topic>CD40L</topic><topic>Circadian Rhythm - physiology</topic><topic>Clinical manifestations. Epidemiology. Investigative techniques. Etiology</topic><topic>Experimental diseases</topic><topic>Humans</topic><topic>hypertension</topic><topic>Hypertension - blood</topic><topic>Hypertension - pathology</topic><topic>Hypertension - physiopathology</topic><topic>isoprostanes</topic><topic>Isoprostanes - blood</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Platelet Activation - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Desideri, Giovambattista</creatorcontrib><creatorcontrib>Cipollone, Francesco</creatorcontrib><creatorcontrib>Valeri, Letizia</creatorcontrib><creatorcontrib>Grassi, Davide</creatorcontrib><creatorcontrib>Necozione, Stefano</creatorcontrib><creatorcontrib>Croce, Giuseppe</creatorcontrib><creatorcontrib>Passacquale, Gabriella</creatorcontrib><creatorcontrib>Garofalo, Angela</creatorcontrib><creatorcontrib>Lippi, Cristina</creatorcontrib><creatorcontrib>Mezzetti, Andrea</creatorcontrib><creatorcontrib>Ferri, Claudio</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of hypertension</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Desideri, Giovambattista</au><au>Cipollone, Francesco</au><au>Valeri, Letizia</au><au>Grassi, Davide</au><au>Necozione, Stefano</au><au>Croce, Giuseppe</au><au>Passacquale, Gabriella</au><au>Garofalo, Angela</au><au>Lippi, Cristina</au><au>Mezzetti, Andrea</au><au>Ferri, Claudio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Enhanced Plasma Soluble CD40 Ligand Levels in Essential Hypertensive Patients With Blunted Nocturnal Blood Pressure Decrease</atitle><jtitle>American journal of hypertension</jtitle><addtitle>AJH</addtitle><date>2007</date><risdate>2007</risdate><volume>20</volume><issue>1</issue><spage>70</spage><epage>76</epage><pages>70-76</pages><issn>0895-7061</issn><eissn>1879-1905</eissn><eissn>1941-7225</eissn><coden>AJHYE6</coden><abstract>Hypertensives with a blunted nocturnal blood pressure (BP) decrease have increased risk of developing atherosclerotic disease. Soluble CD40 ligand (sCD40L) is involved in the pathogenesis of risk factor-related vascular damage. Therefore, we evaluated the relationship between circulating sCD40L levels, circadian BP profile, and early carotid atherosclerosis in essential hypertensives.
Plasma sCD40L concentrations were assessed in two groups of 25 never-treated hypertensives, without additional cardiovascular risk factors, differentiated on the basis of a nocturnal decrease of BP either of >10% (dippers) or <10% (nondippers) of daytime values, and in 25 matched normotensives. Carotid intima–media thickness (IMT) was also measured in all participants.
Plasma sCD40L concentrations were higher in nondippers (4.9 ± 1.2 ng/mL) than in dippers (3.7 ± 0.7,
P = .0005) and controls (1.6 ± 0.6,
P < .0001). These latter had lower sCD40L concentrations than dippers (
P < .0001). The IMT was higher in both hypertensive groups than in normotensives (
P < .0001). In the entire hypertensive population IMT directly correlated with circulating levels of sCD40L (
r = 0.365,
P = .01) and inversely correlated with nocturnal systolic BP decreases (
r = −0.286,
P = .043). In a multivariate regression analysis sCD40L was the main determinant of IMT (
r
2 = 0.157,
P = .004).
Nondippers have enhanced plasma sCD40L levels, which may contribute to their increased susceptibility to develop vascular damage.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>17198914</pmid><doi>10.1016/j.amjhyper.2006.06.007</doi><tpages>7</tpages></addata></record> |
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| ispartof | American journal of hypertension, 2007, Vol.20 (1), p.70-76 |
| issn | 0895-7061 1879-1905 1941-7225 |
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| subjects | Arterial hypertension. Arterial hypotension atherosclerosis Biological and medical sciences Blood and lymphatic vessels Blood Pressure - physiology blood pressure measurement/monitoring C-Reactive Protein - metabolism Cardiology. Vascular system Carotid Artery, Common - pathology CD40 Ligand - blood CD40L Circadian Rhythm - physiology Clinical manifestations. Epidemiology. Investigative techniques. Etiology Experimental diseases Humans hypertension Hypertension - blood Hypertension - pathology Hypertension - physiopathology isoprostanes Isoprostanes - blood Medical sciences Middle Aged Platelet Activation - physiology |
| title | Enhanced Plasma Soluble CD40 Ligand Levels in Essential Hypertensive Patients With Blunted Nocturnal Blood Pressure Decrease |
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