Enhanced Plasma Soluble CD40 Ligand Levels in Essential Hypertensive Patients With Blunted Nocturnal Blood Pressure Decrease

Hypertensives with a blunted nocturnal blood pressure (BP) decrease have increased risk of developing atherosclerotic disease. Soluble CD40 ligand (sCD40L) is involved in the pathogenesis of risk factor-related vascular damage. Therefore, we evaluated the relationship between circulating sCD40L leve...

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Veröffentlicht in:	American journal of hypertension 2007, Vol.20 (1), p.70-76
Hauptverfasser:	Desideri, Giovambattista, Cipollone, Francesco, Valeri, Letizia, Grassi, Davide, Necozione, Stefano, Croce, Giuseppe, Passacquale, Gabriella, Garofalo, Angela, Lippi, Cristina, Mezzetti, Andrea, Ferri, Claudio
Format:	Artikel
Sprache:	eng
Schlagworte:	Arterial hypertension. Arterial hypotension atherosclerosis Biological and medical sciences Blood and lymphatic vessels Blood Pressure - physiology blood pressure measurement/monitoring C-Reactive Protein - metabolism Cardiology. Vascular system Carotid Artery, Common - pathology CD40 Ligand - blood CD40L Circadian Rhythm - physiology Clinical manifestations. Epidemiology. Investigative techniques. Etiology Experimental diseases Humans hypertension Hypertension - blood Hypertension - pathology Hypertension - physiopathology isoprostanes Isoprostanes - blood Medical sciences Middle Aged Platelet Activation - physiology
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Zusammenfassung:	Hypertensives with a blunted nocturnal blood pressure (BP) decrease have increased risk of developing atherosclerotic disease. Soluble CD40 ligand (sCD40L) is involved in the pathogenesis of risk factor-related vascular damage. Therefore, we evaluated the relationship between circulating sCD40L levels, circadian BP profile, and early carotid atherosclerosis in essential hypertensives. Plasma sCD40L concentrations were assessed in two groups of 25 never-treated hypertensives, without additional cardiovascular risk factors, differentiated on the basis of a nocturnal decrease of BP either of >10% (dippers) or
ISSN:	0895-7061 1879-1905 1941-7225
DOI:	10.1016/j.amjhyper.2006.06.007