Saccharide-Induced Peptide Conformation in Glycopeptides of the Recognition Region of LI-Cadherin

The type and the size of the saccharide side chain can affect the conformation of the peptide portion of glycopeptides. This was shown by conformational analysis in solution for a series of glycoundecapeptides with systematically varied tumor‐associated carbohydrate antigens of type A from the recog...

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Veröffentlicht in:	Angewandte Chemie International Edition 2007-01, Vol.46 (3), p.454-458
Hauptverfasser:	Kuhn, Axel, Kunz, Horst
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence cadherins Cadherins - chemistry Carbohydrate Conformation conformational analysis Crystallography, X-Ray glycopeptides Glycopeptides - chemical synthesis Glycopeptides - chemistry Models, Molecular Molecular Sequence Data Nuclear Magnetic Resonance, Biomolecular Protein Structure, Tertiary solid-phase synthesis
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Beschreibung
Zusammenfassung:	The type and the size of the saccharide side chain can affect the conformation of the peptide portion of glycopeptides. This was shown by conformational analysis in solution for a series of glycoundecapeptides with systematically varied tumor‐associated carbohydrate antigens of type A from the recognition region of the cell adhesion glycoprotein LI‐cadherin (gray C, red O, blue N; the saccharide side chain is more intensely colored).
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.200602494