Functional Architecture of HCV IRES Domain II Stabilized by Divalent Metal Ions in the Crystal and in Solution

Functional Architecture of HCV IRES Domain II Stabilized by Divalent Metal Ions in the Crystal and in Solution

Around the bend: A right‐angled bend in the RNA of the hepatitis C virus is stabilized by a core of divalent metal ions (shown as green and violet spheres). Crystal‐structure analysis and fluorescence labeling have been used to investigate the structure and metal‐ion‐dependent stabilization of the R...

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Veröffentlicht in:Angewandte Chemie International Edition 2007, Vol.46 (1-2), p.226-229
Hauptverfasser: Dibrov, Sergey M., Johnston-Cox, Hillary, Weng, Yi-Hsin, Hermann, Thomas
Format: Artikel
Sprache:eng
Schlagworte:
Crystallization
Crystallography, X-Ray
fluorescent probes
Hepacivirus - chemistry
hepatitis C virus
Hydrogen Bonding
Manganese - chemistry
Models, Molecular
molecular recognition
Molecular Structure
Organometallic Compounds - chemistry
Protein Conformation
Protein Structure, Secondary
RNA structures
RNA, Viral - chemistry
Solutions - chemistry
Structure-Activity Relationship
Tungsten - chemistry
X-ray diffraction
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Beschreibung
Zusammenfassung:Around the bend: A right‐angled bend in the RNA of the hepatitis C virus is stabilized by a core of divalent metal ions (shown as green and violet spheres). Crystal‐structure analysis and fluorescence labeling have been used to investigate the structure and metal‐ion‐dependent stabilization of the RNA domain that plays a key role in viral protein synthesis.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200603807