Short-chain aliphatic amines in human urine: a mathematical examination of metabolic interrelationships

Abstract The relationships between several small molecular weight aliphatic amines (methylamine, dimethylamine, trimethylamine, and ethylamine) and an associated N -oxide (trimethylamine N -oxide) quantified in human urine collected from 203 healthy volunteers have been assessed mathematically. Prin...

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Veröffentlicht in:	Metabolism, clinical and experimental clinical and experimental, 2007, Vol.56 (1), p.19-23
Hauptverfasser:	Mitchell, Stephen C, Bollard, Mary E, Zhang, AiQin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Amines - urine Biological and medical sciences Chromatography, Gas Dimethylamines - urine Endocrinology & Metabolism Ethylamines - urine Female Humans Male Medical sciences Metabolic diseases Methylamines - urine Middle Aged Principal Component Analysis
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container_title	Metabolism, clinical and experimental
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creator	Mitchell, Stephen C Bollard, Mary E Zhang, AiQin
description	Abstract The relationships between several small molecular weight aliphatic amines (methylamine, dimethylamine, trimethylamine, and ethylamine) and an associated N -oxide (trimethylamine N -oxide) quantified in human urine collected from 203 healthy volunteers have been assessed mathematically. Principal component analysis highlighted a female subgroup with raised trimethylamine levels and the possibility of hormonal influence on the N-oxidation of trimethylamine has been proposed. A second subgroup of men, who ate a large meal of fish before the study, displayed raised levels of all compounds except ethylamine. In all cases, ethylamine was least significantly correlated with the other urinary components and appeared metabolically unrelated.
doi_str_mv	10.1016/j.metabol.2006.08.017
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subjects	Adult Amines - urine Biological and medical sciences Chromatography, Gas Dimethylamines - urine Endocrinology & Metabolism Ethylamines - urine Female Humans Male Medical sciences Metabolic diseases Methylamines - urine Middle Aged Principal Component Analysis
title	Short-chain aliphatic amines in human urine: a mathematical examination of metabolic interrelationships
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