The risk of disseminated Bacille Calmette-Guerin (BCG) disease in HIV-infected children

Abstract Objectives Bacille Calmette-Guerin (BCG), a live attenuated Mycobacterium bovis vaccine, poses a risk to human immunodeficiency virus (HIV)-infected children; this risk has not been well quantified. We estimate the risk of disseminated BCG disease in HIV-infected children in a setting highl...

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Veröffentlicht in:	Vaccine 2007-01, Vol.25 (1), p.14-18
Hauptverfasser:	Hesseling, Anneke C, Marais, Ben J, Gie, Robert P, Schaaf, H. Simon, Fine, Paul E.M, Godfrey-Faussett, Peter, Beyers, Nulda
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent AIDS-Related Opportunistic Infections - epidemiology AIDS-Related Opportunistic Infections - microbiology Allergy and Immunology Applied microbiology Bacterial diseases BCG BCG Vaccine - administration & dosage BCG Vaccine - adverse effects Biological and medical sciences Child Child, Preschool Children & youth Disease transmission Disseminated Female Fundamental and applied biological sciences. Psychology HIV HIV Infections - complications HIV Infections - epidemiology HIV Infections - immunology Human bacterial diseases Human immunodeficiency virus Human viral diseases Humans Immunization Incidence Infant Infant, Newborn Infants Infectious Disease Transmission, Vertical Infectious diseases Medical sciences Microbiology Miscellaneous Mycobacterium bovis Mycobacterium bovis - immunology Mycobacterium bovis - pathogenicity Public health Risk Factors South Africa - epidemiology Tuberculosis Tuberculosis - complications Tuberculosis - epidemiology Tuberculosis - microbiology Tuberculosis - prevention & control Tuberculosis and atypical mycobacterial infections Vaccination - statistics & numerical data Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Virology
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Zusammenfassung:	Abstract Objectives Bacille Calmette-Guerin (BCG), a live attenuated Mycobacterium bovis vaccine, poses a risk to human immunodeficiency virus (HIV)-infected children; this risk has not been well quantified. We estimate the risk of disseminated BCG disease in HIV-infected children in a setting highly endemic for tuberculosis and HIV. Design and methods We conducted a prospective hospital-based surveillance study in the Western Cape Province, South Africa. Clinical and laboratory-confirmed cases of disseminated BCG disease in children
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2006.07.020