Scintigraphic imaging with a peptide glucuronide in rabbits: 99mTc- exorphin C glucuronide

A peptide glucuronide (Exorphin C glucuronide) was labeled with 99mTc using glucoheptonate (GH) as a bifunctional chelating agent. Scintigraphic imaging was performed in male Albino rabbits. Exorphin C glucuronide showed rapid and efficient labeling with 99mTc using glucoheptonate as a bifunctional...

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Veröffentlicht in:	Applied radiation and isotopes 2007-02, Vol.65 (2), p.170-175
Hauptverfasser:	Ertay, T., Ünak, P., Biber, F.Z., Tascı, C., Zihnioğlu, F., Durak, H.
Format:	Artikel
Sprache:	eng
Schlagworte:	99mTc-GE 99mTc-GEG 99mTc-labeled peptides Animals Brain - diagnostic imaging Brain - metabolism Exophin C Exophin C glucuronide Female Glucuronides - pharmacokinetics Hemoglobins - pharmacokinetics In Vitro Techniques Male Microsomes - metabolism Microsomes, Liver - metabolism Organotechnetium Compounds - pharmacokinetics Peptide Fragments - pharmacokinetics Rabbits Radionuclide Imaging Radiopharmaceuticals - pharmacokinetics Rats Rats, Wistar Receptors, Opioid - metabolism Scintigraphy Sugar Acids - chemistry Technetium Tissue Distribution
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Zusammenfassung:	A peptide glucuronide (Exorphin C glucuronide) was labeled with 99mTc using glucoheptonate (GH) as a bifunctional chelating agent. Scintigraphic imaging was performed in male Albino rabbits. Exorphin C glucuronide showed rapid and efficient labeling with 99mTc using glucoheptonate as a bifunctional chelate. Results demonstrated that 99mTc-GEG may be a useful new type of glucuronide derivative of peptides for diagnosis of some cancer diseases.
ISSN:	0969-8043 1872-9800
DOI:	10.1016/j.apradiso.2006.03.017