Expression of P-glycoprotein and metallothionein in gastrointestinal stromal tumor and leiomyosarcomas. Clinical implications

We investigated the expression of P-glycoprotein (P-GP) and metallothionein (MT) in a series of 92 GIST and 14 gastrointestinal leiomyosarcomas (GILMS) with the purpose to expand our knowledge on the biological bases of GIST chemo-resistance and to ascertain their significance in patients' prog...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Pathology oncology research 2007-01, Vol.13 (3), p.203-208
Hauptverfasser:	Pérez-Gutiérrez, Sofia, González-Cámpora, Ricardo, Amérigo-Navarro, Joaquín, Beato-Moreno, Antonio, Sánchez-León, María, Pareja Megía, Jesús María, Virizuela-Echaburu, Juan Antonio, López-Beltrán, Antonio
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Antineoplastic Agents - therapeutic use Antiretroviral drugs ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism Drug Resistance, Neoplasm Drug therapy Female Gastrointestinal Neoplasms - diagnosis Gastrointestinal Neoplasms - drug therapy Gastrointestinal Neoplasms - metabolism Gastrointestinal Stromal Tumors - diagnosis Gastrointestinal Stromal Tumors - drug therapy Gastrointestinal Stromal Tumors - metabolism Gene Expression Regulation, Neoplastic Humans Leiomyosarcoma - diagnosis Leiomyosarcoma - drug therapy Leiomyosarcoma - metabolism Male Metallothionein - metabolism Middle Aged Oncology Pathology Prognosis Survival Analysis
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	We investigated the expression of P-glycoprotein (P-GP) and metallothionein (MT) in a series of 92 GIST and 14 gastrointestinal leiomyosarcomas (GILMS) with the purpose to expand our knowledge on the biological bases of GIST chemo-resistance and to ascertain their significance in patients' prognosis. P-GP expression was more frequent in GIST than in GI-LMS (83.7% vs. 21.4%, p
ISSN:	1219-4956 1532-2807
DOI:	10.1007/BF02893500