Low Sensitivity of a Whole-Blood Interferon-γ Release Assay for Detection of Active Tuberculosis

The sensitivity of an interferon-γ assay (Quantiferon-TB Gold; Cellestis) was evaluated for the detection of tuberculosis among 242 persons with suspected tuberculosis in San Francisco, California. Thirty-seven subjects had culture-confirmed tuberculosis. Excluding 1 indeterminate result, 23 (64%; 9...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Clinical infectious diseases 2007-01, Vol.44 (1), p.69-73
Hauptverfasser:	Dewan, Puneet K., Grinsdale, Jennifer, Kawamura, L. Masae
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Brief Reports Child Child, Preschool Cutaneous tuberculosis False Negative Reactions HIV infections Humans Infant Infant, Newborn Infections Interferon-gamma - blood Latent tuberculosis Middle Aged Mycobacterium Mycobacterium tuberculosis Mycobacterium tuberculosis - immunology Patient medical history Predictive Value of Tests Public health Pulmonary tuberculosis Reagent Kits, Diagnostic San Francisco Sensitivity and Specificity Tuberculin Tuberculin Test Tuberculosis Tuberculosis - diagnosis Tuberculosis - immunology Tuberculosis, Pulmonary - diagnosis Tuberculosis, Pulmonary - immunology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The sensitivity of an interferon-γ assay (Quantiferon-TB Gold; Cellestis) was evaluated for the detection of tuberculosis among 242 persons with suspected tuberculosis in San Francisco, California. Thirty-seven subjects had culture-confirmed tuberculosis. Excluding 1 indeterminate result, 23 (64%; 95% confidence interval, 48%-78%) of 36 subjects had positive results using the QuantiFERON-TB Gold assay. The 64% sensitivity suggests that the QuantiFERON-TB Gold assay should not be used alone to exclude active tuberculosis.
ISSN:	1058-4838 1537-6591
DOI:	10.1086/509928