Complanadines C and D, new dimeric alkaloids from Lycopodium complanatum

Two new dimeric Lycopodium alkaloids, complanadines C ( 1) and D ( 2), have been isolated from the club moss Lycopodium complanatum, and the structures and relative stereochemistry of 1 and 2 were elucidated on the basis of the spectral data. Complanadine D ( 2) enhanced mRNA expression for NGF.

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2007, Vol.15 (1), p.413-417
Hauptverfasser:	Ishiuchi, Kan’ichiro, Kubota, Takaaki, Mikami, Yuzuru, Obara, Yutaro, Nakahata, Norimichi, Kobayashi, Jun’ichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaloids - chemistry Alkaloids - isolation & purification Complanadines C and D Dimerization Heterocyclic Compounds, 4 or More Rings - chemistry Heterocyclic Compounds, 4 or More Rings - isolation & purification Lycopodium Lycopodium - chemistry Lycopodium alkaloids Lycopodium complanatum Magnetic Resonance Spectroscopy - methods Magnetic Resonance Spectroscopy - standards Models, Molecular Molecular Conformation Reference Standards Stereoisomerism
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Beschreibung
Zusammenfassung:	Two new dimeric Lycopodium alkaloids, complanadines C ( 1) and D ( 2), have been isolated from the club moss Lycopodium complanatum, and the structures and relative stereochemistry of 1 and 2 were elucidated on the basis of the spectral data. Complanadine D ( 2) enhanced mRNA expression for NGF.
ISSN:	0968-0896 1464-3391
DOI:	10.1016/j.bmc.2006.09.043