Translation from Research to Applications
The article summarizes the collective views expressed at the fourth session of the workshop Tissue Engineering-the Next Generation, which was devoted to the translation of results of tissue engineering research into applications. Ernst Hunziker described the paradigm of a dual translational approach...
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Veröffentlicht in: | Tissue engineering 2006-12, Vol.12 (12), p.3341-3364 |
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Sprache: | eng |
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Zusammenfassung: | The article summarizes the collective views expressed at the fourth session of the workshop Tissue
Engineering-the Next Generation, which was devoted to the translation of results of tissue engineering research
into applications. Ernst Hunziker described the paradigm of a dual translational approach, and argued
that tissue engineering should be guided by the dimensions and physiological setting of the bodily compartment
to be repaired. Myron Spector discussed collagen-glycosaminoglycan (GAG) scaffolds for musculoskeletal
tissue engineering. Jeanette Libera focused on the biological and clinical aspects of cartilage tissue
engineering, and described a completely autologous procedure for engineering cartilage using the patient's
own chondrocytes and blood serum. Arthur Gertzman reviewed the applications of allograft tissues in orthopedic
surgery, and outlined the potential of allograft tissues as models for biological and medical studies.
Savio Woo discussed a list of functional tissue engineering approaches designed to restore the biochemical
and biomechanical properties of injured ligaments and tendons to be closer to that of the normal tissues.
Specific examples of using biological scaffolds that have chemoattractants as well as growth factors with
unique contact guidance properties to improve their healing process were shown. Anthony Ratcliffe discussed
the translation of the results of research into products that are profitable and meet regulatory requirements.
Michael Lysaght challenged the proposition that commercial and clinical failures of early tissue engineering
products demonstrate a need for more focus on basic research. Arthur Coury described the evolution of tissue
engineering products based on the example of Genzyme, and how various definitions of success and failure
can affect perceptions and policies relative to the status and advancement of the field of tissue engineering. |
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ISSN: | 1076-3279 1557-8690 |
DOI: | 10.1089/ten.2006.12.3341 |