Assessing Iron Status: Beyond Serum Ferritin and Transferrin Saturation

The increasing prevalence of multiple comorbidities among anemic patients with chronic kidney disease has made the use of serum ferritin and transferrin saturation more challenging in diagnosing iron deficiency. Because serum ferritin is an acute-phase reactant and because the inflammatory state may...

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Veröffentlicht in:	Clinical journal of the American Society of Nephrology 2006-09, Vol.1 (Supplement 1), p.S4-S8
1. Verfasser:	Wish, Jay B
Format:	Artikel
Sprache:	eng
Schlagworte:	Anemia, Iron-Deficiency - blood Anemia, Iron-Deficiency - diagnosis Anemia, Iron-Deficiency - drug therapy Anemia, Iron-Deficiency - etiology Antimicrobial Cationic Peptides - blood Biomarkers - blood Erythrocytes - pathology Ferritins - blood Hematinics - administration & dosage Hemoglobins - metabolism Hepcidins Humans Infusions, Intravenous Iron - blood Iron Compounds - administration & dosage Patient Selection Practice Guidelines as Topic Predictive Value of Tests Quality of Health Care Receptors, Transferrin - blood Renal Dialysis Renal Insufficiency, Chronic - blood Renal Insufficiency, Chronic - complications Renal Insufficiency, Chronic - therapy Reticulocytes - metabolism Sensitivity and Specificity Transferrin - metabolism
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Beschreibung
Zusammenfassung:	The increasing prevalence of multiple comorbidities among anemic patients with chronic kidney disease has made the use of serum ferritin and transferrin saturation more challenging in diagnosing iron deficiency. Because serum ferritin is an acute-phase reactant and because the inflammatory state may inhibit the mobilization of iron from reticuloendothelial stores, the scenario of patients with serum ferritin >800 ng/ml, suggesting iron overload, and transferrin saturation
ISSN:	1555-9041 1555-905X
DOI:	10.2215/CJN.01490506