Hemostatic system parameters of placental extracts in normal pregnancy and severe preeclampsia

Hemostatic system parameters of placental extracts in normal pregnancy and severe preeclampsia

To better understand the role of the hemostatic mechanism in preeclampsia, placental extracts obtained from 26 normal pregnant women (NP) and 12 patients with severe pre-eclampsia (SPE) were analyzed to determine thrombomodulin (TM), tissue factor (TF), tissue-type plasminogen activator (tPA), plasm...

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Veröffentlicht in:Investigación clínica 2006-09, Vol.47 (3), p.233-240
Hauptverfasser: López-Ramírez, Ysabel, Carvajal, Zoila, Arocha-Piñango, Carmen Luisa
Format: Artikel
Sprache:spa
Schlagworte:
Adolescent
Adult
Blood Coagulation Factors - analysis
Female
Hemostasis
Humans
Placenta - chemistry
Pre-Eclampsia - blood
Pregnancy
Severity of Illness Index
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Zusammenfassung:To better understand the role of the hemostatic mechanism in preeclampsia, placental extracts obtained from 26 normal pregnant women (NP) and 12 patients with severe pre-eclampsia (SPE) were analyzed to determine thrombomodulin (TM), tissue factor (TF), tissue-type plasminogen activator (tPA), plasminogen activator inhibitor (PAI) 1 and 2, and TF pathway inhibitor (TFPI). The results showed similar concentrations of TF, TM and PAI-2 in both groups, while tPA increased no significantly and TFPI and PAI-1 increased significantly in SPE placentas.
ISSN:0535-5133