Microarray Strategy for Mapping the Substrate Specificity of Protein Tyrosine Phosphatase

Microarray Strategy for Mapping the Substrate Specificity of Protein Tyrosine Phosphatase

Which substrate will it be? Phosphotyrosine peptide microarrays have allowed the substrate specificity to be mapped for two prototypical protein‐tyrosine phosphatases (PTPs): PTP1B and PTPμ. The knowledge gained was used for molecular docking studies (see picture: the docking of a peptide in the bin...

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Veröffentlicht in:Angewandte Chemie (International ed.) 2007-01, Vol.46 (40), p.7700-7703
Hauptverfasser: Köhn, Maja, Gutierrez-Rodriguez, Marta, Jonkheijm, Pascal, Wetzel, Stefan, Wacker, Ron, Schroeder, Hendrik, Prinz, Heino, Niemeyer, Christof M, Breinbauer, Rolf, Szedlacsek, Stefan E, Waldmann, Herbert
Format: Artikel
Sprache:eng
Schlagworte:
Amino Acids - chemistry
Binding Sites
Color
enzymes
inhibitors
microarrays
Models, Molecular
Molecular Structure
peptides
Peptides - chemistry
Phosphotyrosine - chemistry
Protein Array Analysis - methods
Protein Tyrosine Phosphatases - chemistry
Protein Tyrosine Phosphatases - metabolism
Substrate Specificity
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Zusammenfassung:Which substrate will it be? Phosphotyrosine peptide microarrays have allowed the substrate specificity to be mapped for two prototypical protein‐tyrosine phosphatases (PTPs): PTP1B and PTPμ. The knowledge gained was used for molecular docking studies (see picture: the docking of a peptide in the binding pocket of PTPμ) and the design of an inhibitor for PTPμ.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200701601