Analysis of antidiuretic effect of arginine-vasotocin and its analogs in primates

Intramuscular injection of synthetic analogs of arginine-vasotocin to monkeys after 3% water loading caused antidiuretic reaction, manifesting by reabsorption of osmotically free water and paralleled by significant changes in excretion of sodium or potassium ions. It is shown that synthetic analogs...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2006-12, Vol.142 (6), p.714-716
Hauptverfasser:	Buravkova, L B, Larina, I M, Korolkov, V I, Dobrokhotov, I V, Grigorev, A I
Format:	Artikel
Sprache:	eng ; rus
Schlagworte:	Animals Antidiuretic Agents - pharmacology Antidiuretics Arginine Vasopressin - analogs & derivatives Arginine Vasopressin - pharmacology Diuresis - drug effects Diuretics - pharmacology Ions - metabolism Macaca mulatta - physiology Male Osmolar Concentration Potassium - metabolism Reabsorption Sodium - metabolism Vasotocin Vasotocin - pharmacology
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Beschreibung
Zusammenfassung:	Intramuscular injection of synthetic analogs of arginine-vasotocin to monkeys after 3% water loading caused antidiuretic reaction, manifesting by reabsorption of osmotically free water and paralleled by significant changes in excretion of sodium or potassium ions. It is shown that synthetic analogs can be more effective and selective than natural agonists.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-006-0459-7