Asymmetric Synthesis of 3,4-Dihydrocoumarins by Rhodium-Catalyzed Reaction of 3-(2-Hydroxyphenyl)cyclobutanones

Asymmetric Synthesis of 3,4-Dihydrocoumarins by Rhodium-Catalyzed Reaction of 3-(2-Hydroxyphenyl)cyclobutanones

3,4-Dihydrocoumarin derivatives were synthesized in a highly enantioselective manner from 3-(2-hydroxyphenyl)cyclobutanones through enantioselective carbon−carbon bond cleavage. A cascade reaction with electron-deficient alkenes introduced a carbon−carbon bond at the 5-position of the dihydrocoumari...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of the American Chemical Society 2007-10, Vol.129 (40), p.12086-12087
Hauptverfasser: Matsuda, Takanori, Shigeno, Masanori, Murakami, Masahiro
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:3,4-Dihydrocoumarin derivatives were synthesized in a highly enantioselective manner from 3-(2-hydroxyphenyl)cyclobutanones through enantioselective carbon−carbon bond cleavage. A cascade reaction with electron-deficient alkenes introduced a carbon−carbon bond at the 5-position of the dihydrocoumarins.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja075141g