Epicoccins A–D, Epipolythiodioxopiperazines from a Cordyceps-Colonizing Isolate of Epicoccum nigrum

Epicoccins A–D (1–4), four unique epipolythiodioxopiperazines possessing unusual sulfur bridges, have been isolated from cultures of a Cordyceps-colonizing isolate of Epicoccum nigrum. The structures of these compounds were determined mainly by analysis of their NMR spectroscopic data. The relative...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2007-09, Vol.70 (9), p.1522-1525
Hauptverfasser:	Zhang, Yonggang, Liu, Shuchun, Che, Yongsheng, Liu, Xingzhong
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Infective Agents - chemistry Anti-Infective Agents - isolation & purification Anti-Infective Agents - pharmacology antibacterial properties Antibiotics (antibacterial agents, antifungal agents) Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents Applied microbiology Ascomycota - chemistry Biological and medical sciences chemical structure Cordyceps Cordyceps - chemistry Crystallography, X-Ray epicoccin Epicoccum nigrum epipolythiodioxopiperazine Fundamental and applied biological sciences. Psychology Microbiology Molecular Conformation Molecular Structure Nuclear Magnetic Resonance, Biomolecular piperazines Piperazines - chemistry Piperazines - isolation & purification Piperazines - pharmacology spectral analysis stereochemistry Tibet
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Zusammenfassung:	Epicoccins A–D (1–4), four unique epipolythiodioxopiperazines possessing unusual sulfur bridges, have been isolated from cultures of a Cordyceps-colonizing isolate of Epicoccum nigrum. The structures of these compounds were determined mainly by analysis of their NMR spectroscopic data. The relative and absolute configuration of epicoccin A (1) was established by single-crystal X-ray diffraction analysis. Epicoccin A (1) showed modest antimicrobial activity.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np070239u