Synthesis and biological activities of quinazoline derivatives with ortho-phenol-quaternary ammonium salt groups

One phenol-quaternary ammonium salt derivative with a flexible linker and three derivatives with a quinazoline moiety were present. Their binding affinities for DNA were discussed and it is clearly demonstrated that this class of phenol-quaternary ammonium salt derivatives could inhibit DNA transcription effectively. One phenol-quaternary ammonium salt derivative with a flexible linker and three derivatives with a quinazoline moiety are present. Their binding affinities for DNA are discussed and it is clearly demonstrated that this class of phenol-quaternary ammonium salt derivatives could inhibit DNA transcription effectively.