Relationship of 5-HTTLPR genotypes and depression risk in the presence of trauma in a female twin sample

Several studies have implicated an insertion/deletion polymorphism in the promoter region of the serotonin transporter gene (SLC6A4; 5‐HTT) in the development of mood disorders. In the present study of a sample of 247 young adult female twins from Missouri, we examine whether this polymorphism inter...

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Veröffentlicht in:	American journal of medical genetics. Part B, Neuropsychiatric genetics Neuropsychiatric genetics, 2007-09, Vol.144B (6), p.830-833
Hauptverfasser:	Chorbov, Vesselin M., Lobos, Elizabeth A., Todorov, Alexandre A., Heath, Andrew C., Botteron, Kelly N., Todd, Richard D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Adult and adolescent clinical studies Alleles Biological and medical sciences Depression Depressive Disorder, Major - etiology Depressive Disorder, Major - genetics Female functional polymorphism gene-environment interaction Genotype Humans Medical genetics Medical sciences Miscellaneous Mood disorders Prospective Studies Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Risk Factors Serotonin Plasma Membrane Transport Proteins - genetics serotonin transporter trauma Wounds and Injuries - complications
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Zusammenfassung:	Several studies have implicated an insertion/deletion polymorphism in the promoter region of the serotonin transporter gene (SLC6A4; 5‐HTT) in the development of mood disorders. In the present study of a sample of 247 young adult female twins from Missouri, we examine whether this polymorphism interacts with the effect of adverse life events to increase risk for developing depression. We found a significant interaction between the number of high‐activity LA alleles and exposure to trauma (OR = 1.70, P
ISSN:	1552-4841 1552-485X
DOI:	10.1002/ajmg.b.30534