HDL Cholesterol, Very Low Levels of LDL Cholesterol, and Cardiovascular Events

HDL Cholesterol, Very Low Levels of LDL Cholesterol, and Cardiovascular Events

In a post hoc analysis of the Treating to New Targets study, high-density lipoprotein cholesterol levels in patients receiving statin therapy were shown to be predictive of subsequent major cardiovascular events, even when low-density lipoprotein (LDL) cholesterol levels were taken into account and...

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Veröffentlicht in:The New England journal of medicine 2007-09, Vol.357 (13), p.1301-1310
Hauptverfasser: Barter, Philip, Gotto, Antonio M, LaRosa, John C, Maroni, Jaman, Szarek, Michael, Grundy, Scott M, Kastelein, John J.P, Bittner, Vera, Fruchart, Jean-Charles
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Aged
Anticholesteremic Agents - therapeutic use
Apolipoproteins - blood
Atorvastatin Calcium
Biological and medical sciences
Cardiovascular disease
Cardiovascular Diseases - epidemiology
Cholesterol
Cholesterol, HDL - blood
Cholesterol, LDL - blood
Coronary Disease - blood
Coronary Disease - drug therapy
Double-Blind Method
Female
General aspects
Heptanoic Acids - administration & dosage
Heptanoic Acids - therapeutic use
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage
Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use
Hypercholesterolemia - drug therapy
Low density lipoprotein
Male
Medical sciences
Middle Aged
Multivariate Analysis
Pyrroles - administration & dosage
Pyrroles - therapeutic use
Risk
Risk factors
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Beschreibung
Zusammenfassung:In a post hoc analysis of the Treating to New Targets study, high-density lipoprotein cholesterol levels in patients receiving statin therapy were shown to be predictive of subsequent major cardiovascular events, even when low-density lipoprotein (LDL) cholesterol levels were taken into account and even among patients with very low levels of LDL cholesterol (
ISSN:0028-4793
1533-4406
DOI:10.1056/NEJMoa064278