Rheumatoid course of humoral (vascular) rejection after heart allotransplantation

Analysis of planned endomyocardial biopsy specimens of heart allotransplants from 22 recipients revealed signs of humoral type rejection (slight, medium, and severe) presenting as fixation of IgG, IgM, and complement components (C3, C4d) in 61 of 63 sections. Permanent presence of rejection signs at...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2006-09, Vol.142 (3), p.363-366
Hauptverfasser:	Beletskaya, L V, Kupriyanova, A G, Kormer, A Ya, Mironkov, B L, Kazakov, E N, Shumakov, V I
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biopsy Capillaries - chemistry Capillaries - immunology Complement C3 - immunology Complement C4b - immunology Coronary Vessels - chemistry Coronary Vessels - immunology Female Fluorescein-5-isothiocyanate Fluorescent Antibody Technique, Direct Fluorescent Dyes Graft Rejection - immunology Graft Rejection - pathology Heart Transplantation - immunology Heart Transplantation - pathology Humans Immunoglobulin G - immunology Immunoglobulin M - immunology Immunohistochemistry Male Myocardium - immunology Peptide Fragments - immunology Transplantation, Homologous
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Zusammenfassung:	Analysis of planned endomyocardial biopsy specimens of heart allotransplants from 22 recipients revealed signs of humoral type rejection (slight, medium, and severe) presenting as fixation of IgG, IgM, and complement components (C3, C4d) in 61 of 63 sections. Permanent presence of rejection signs attests to rheumatoid course of this process.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-006-0367-x