Multiphase Organic Synthesis in Microchannel Reactors

“Miniaturization” is one of the most important aspects in today’s technology. Organic chemistry is no exception. The search for highly effective, controllable, environmentally friendly methods for preparing products is of prime importance. The development of multiphase organic reactions in microchannel reactors has gained significant importance in recent years to allow novel reactivity, and has led to many fruitful results that are not attainable in conventional reactors. This Focus Review aims to shed light on how effectively multiphase organic reactions can be conducted with microchannel reactors by providing examples of recent remarkable studies, which have been grouped on the basis of the phases involved. Channelling efforts: Multiphase organic reactions can be conducted effectively in microchannel reactors. A variety of organic reactions have been optimized for such systems by exploiting different aspects, such as high specific interfacial area, short molecular diffusion distance, high efficiency for heat transfer, and so on. The Focus Review categorizes these multiphase reactions on the basis of the phases involved.