Relationship between natural concentration of heavy water isotopologs and rate of H2O2 generation by mitochondria

Relationship between natural concentration of heavy water isotope homologs in natural water and the kinetics of H(2)O(2) generation by isolated rat liver mitochondria in the presence of succinic acid as the substrate was studied. Natural concentrations of heavy water isotopologs significantly inhibi...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2006-11, Vol.142 (5), p.570-572
Hauptverfasser:	Pomytkin, I A, Kolesova, O E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Deuterium Oxide - analysis Deuterium Oxide - metabolism Hydrogen Peroxide - metabolism Male Mitochondria, Liver - metabolism Rats Rats, Wistar Succinic Acid - metabolism
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Zusammenfassung:	Relationship between natural concentration of heavy water isotope homologs in natural water and the kinetics of H(2)O(2) generation by isolated rat liver mitochondria in the presence of succinic acid as the substrate was studied. Natural concentrations of heavy water isotopologs significantly inhibited the studied reaction. The decrease in heavy isotopolog content in natural water leads to disinhibition and significant acceleration of the studied reaction.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-006-0420-9