Anti-Ro and anti-La autoantibodies induce TNF-alpha production by human salivary gland cells: an in vitro study

In this report, we demonstrate that both TNFR1 and the TNFR2 are expressed on the salivary gland cell line A-253 cell membrane. Furthermore, cell treatment with anti-Ro and anti-La autoantibodies from Sjögren IgG determined TNF-alpha production, clarifying which could be the inducer of the extrinsic...

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Veröffentlicht in:	Reumatismo 2007-07, Vol.59 (3), p.221-226
Hauptverfasser:	Sisto, M, Lisi, S, D'Amore, M, Mitolo, V, Scagliusi, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Antinuclear - immunology Antibodies, Antinuclear - isolation & purification Antibodies, Antinuclear - pharmacology Apoptosis - physiology Autoantigens - immunology Carcinoma, Squamous Cell - pathology Cell Line, Tumor - metabolism Gene Expression Regulation - immunology Humans Immunoglobulin G - immunology Immunoglobulin G - isolation & purification Immunoglobulin G - pharmacology In Vitro Techniques Receptors, Tumor Necrosis Factor, Type I - biosynthesis Receptors, Tumor Necrosis Factor, Type I - genetics Receptors, Tumor Necrosis Factor, Type II - biosynthesis Receptors, Tumor Necrosis Factor, Type II - genetics Ribonucleoproteins - immunology Salivary Gland Neoplasms - pathology Sjogren's Syndrome - immunology SS-B Antigen Submandibular Gland - cytology Tumor Necrosis Factor-alpha - biosynthesis Tumor Necrosis Factor-alpha - genetics
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Zusammenfassung:	In this report, we demonstrate that both TNFR1 and the TNFR2 are expressed on the salivary gland cell line A-253 cell membrane. Furthermore, cell treatment with anti-Ro and anti-La autoantibodies from Sjögren IgG determined TNF-alpha production, clarifying which could be the inducer of the extrinsic pathway of apoptosis in salivary gland cells.
ISSN:	0048-7449 2240-2683
DOI:	10.4081/reumatismo.2007.221