Effect of mesenchymal stem cells on rejection of xenogenic bone transplant

We studied the effects of mesenchymal stem cells on rejection of xenogenic bone transplant. Experiments were carried out on Wistar-Kyoto rats transplanted chicken demineralized bone matrix populated or not populated with mesenchymal stem cells to the site of parietal bone defect. Histological analysis showed complete resorption of the xenogenic transplant not populated with mesenchymal stem cells by day 119. In experimental animals chicken matrix without signs of tissue inflammation was in fact completely retained over the entire period of observation. Numerous new vessels, mineralization fields, and areas of bone tissue formation were seen in the transplant.