Effect of mexidol and nitroglycerine on iron-sulfur centers, cytochrome P-450, and nitric oxide formation in liver tissue of experimental animals

In experiments on mice we studied the effect of individual or combined treatment with mexidol and nitroglycerine on iron-sulfur centers of the mitochondrial respiratory chain, cytochrome P-450 of the endoplasmic reticulum, and nitric oxide formation in the liver tissue. Mexidol had a potent effect o...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2006-10, Vol.142 (4), p.422-424
Hauptverfasser:	Belaya, O L, Baider, L M, Kuropteva, Z V
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cytochrome P-450 Enzyme System - drug effects Cytochrome P-450 Enzyme System - metabolism Electron Spin Resonance Spectroscopy Iron-Sulfur Proteins - drug effects Iron-Sulfur Proteins - metabolism Liver - drug effects Liver - metabolism Male Mice Nitric Oxide - biosynthesis Nitroglycerin - pharmacology Picolines - pharmacology Platelet Aggregation Inhibitors - pharmacology Rats Rats, Inbred SHR Vasodilator Agents - pharmacology
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Zusammenfassung:	In experiments on mice we studied the effect of individual or combined treatment with mexidol and nitroglycerine on iron-sulfur centers of the mitochondrial respiratory chain, cytochrome P-450 of the endoplasmic reticulum, and nitric oxide formation in the liver tissue. Mexidol had a potent effect on these parameters and protected iron-sulfur centers from oxidation, including that induced by nitroglycerine.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-006-0382-y