Positional Assembly of Enzymes in Polymersome Nanoreactors for Cascade Reactions

In a good position: Nanoreactors can be constructed by the controlled positioning of glucose oxidase (GOX) and horseradish peroxidase (HRP) within the central water pool and block‐copolymer membrane of polymersomes. A one‐pot multistep reaction sequence is performed with the nanoreactor in combinati...

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Veröffentlicht in:	Angewandte Chemie (International ed.) 2007-01, Vol.46 (39), p.7378-7382
Hauptverfasser:	Vriezema, Dennis M, Garcia, Paula M.L, Sancho Oltra, Núria, Hatzakis, Nikos S, Kuiper, Suzanne M, Nolte, Roeland J.M, Rowan, Alan E, van Hest, Jan C.M
Format:	Artikel
Sprache:	eng
Schlagworte:	cascade reactions catalysis enzymes Enzymes - chemistry Enzymes - metabolism Glucose Oxidase - chemistry Glucose Oxidase - metabolism Horseradish Peroxidase - chemistry Horseradish Peroxidase - metabolism Hydrogen-Ion Concentration Kinetics Lipase - chemistry Lipase - metabolism Microscopy, Electron, Transmission Molecular Structure Nanoparticles - chemistry Nanoparticles - ultrastructure Polymers - chemistry polymersomes Spectrophotometry Substrate Specificity supramolecular chemistry
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Beschreibung
Zusammenfassung:	In a good position: Nanoreactors can be constructed by the controlled positioning of glucose oxidase (GOX) and horseradish peroxidase (HRP) within the central water pool and block‐copolymer membrane of polymersomes. A one‐pot multistep reaction sequence is performed with the nanoreactor in combination with free Candida antarctica lipase B (CALB) in the bulk solution (see picture; ABTS: 2,2′‐azinobis(3‐ethylbenzothiazoline‐6‐sulfonic acid)).
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.200701125