Thrombin Generation Assay and Viscoelastic Coagulation Monitors Demonstrate Differences in the Mode of Thrombin Inhibition Between Unfractionated Heparin and Bivalirudin

Thrombin Generation Assay and Viscoelastic Coagulation Monitors Demonstrate Differences in the Mode of Thrombin Inhibition Between Unfractionated Heparin and Bivalirudin

Coagulation tests, such as activated partial thromboplastin time and activated clotting time, are used to monitor the effects of unfractionated heparin and the direct thrombin inhibitor, bivalirudin. These tests reflect only the initial phase of blood clotting, when

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Bibliographische Detailangaben
Veröffentlicht in:Anesthesia and analgesia 2007-10, Vol.105 (4), p.933-939
Hauptverfasser: Tanaka, Kenichi A., Szlam, Fania, Sun, He Ying, Taketomi, Taro, Levy, Jerrold H.
Format: Artikel
Sprache:eng
Schlagworte:
Anesthesia
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Anticoagulants - pharmacology
Antithrombins - pharmacology
Biological and medical sciences
Blood Viscosity - drug effects
Dose-Response Relationship, Drug
Heparin - pharmacology
Hirudins - pharmacology
Humans
In Vitro Techniques
Medical sciences
Peptide Fragments - biosynthesis
Peptide Fragments - pharmacology
Prothrombin - biosynthesis
Recombinant Proteins - pharmacology
Thrombelastography
Thrombin - antagonists & inhibitors
Thrombin - biosynthesis
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Zusammenfassung:Coagulation tests, such as activated partial thromboplastin time and activated clotting time, are used to monitor the effects of unfractionated heparin and the direct thrombin inhibitor, bivalirudin. These tests reflect only the initial phase of blood clotting, when
ISSN:0003-2999
1526-7598
DOI:10.1213/01.ane.0000278868.23814.3b