JAM Family and Related Proteins in Leukocyte Migration (Vestweber Series)

Exploring the role of junctional adhesion molecules (JAMs) has proven to be varied and controversial. The purpose of this review is to discuss the new and exciting roles of these IgSF molecules and how they have evolved to contribute to diverse functions from development to inflammation. In particul...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2007-10, Vol.27 (10), p.2104-2112
Hauptverfasser:	Bradfield, Paul F, Nourshargh, Sussan, Aurrand-Lions, Michel, Imhof, Beat A
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Associated diseases and complications Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cell Adhesion Molecules - chemistry Cell Adhesion Molecules - immunology Cell Adhesion Molecules - metabolism Diabetes. Impaired glucose tolerance Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Endocrine pancreas. Apud cells (diseases) Endocrinopathies Endothelial Cells - immunology Endothelial Cells - metabolism Humans Inflammation - metabolism Junctional Adhesion Molecules Leukocyte Rolling - immunology Leukocytes - immunology Leukocytes - metabolism Ligands Medical sciences Miscellaneous Molecular Sequence Data Multiprotein Complexes - metabolism Protein Isoforms - metabolism Protein Structure, Tertiary Signal Transduction - immunology
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Zusammenfassung:	Exploring the role of junctional adhesion molecules (JAMs) has proven to be varied and controversial. The purpose of this review is to discuss the new and exciting roles of these IgSF molecules and how they have evolved to contribute to diverse functions from development to inflammation. In particular, recent research has focused on JAM subfamily members JAM-A, -B, and -C with newly described roles in leukocyte trafficking during inflammation and angiogenesis. However, research on all JAM family members has demonstrated recurring themes with striking similarities in the many diverse processes they are now known to regulate.
ISSN:	1079-5642 1524-4636
DOI:	10.1161/ATVBAHA.107.147694