NAD(P)H oxidase p22phox C242T polymorphism and ischemic stroke in Japan: the Fukuoka Stroke Registry and the Hisayama study

NAD(P)H oxidase p22phox C242T polymorphism and ischemic stroke in Japan: the Fukuoka Stroke Registry and the Hisayama study

The C242T polymorphism of p22phox, a component of NAD(P)H oxidase, may have an impact on cardiovascular diseases; however, the association between this polymorphism and brain infarction is not fully understood. Here, we investigate the relationship between the C242T polymorphism and brain infarction...

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Veröffentlicht in:European journal of neurology 2007-10, Vol.14 (10), p.1091-1097
Hauptverfasser: Kuroda, J., Kitazono, T., Ago, T., Ninomiya, T., Ooboshi, H., Kamouchi, M., Kumai, Y., Hagiwara, N., Yoshimura, S., Tamaki, K., Kusuda, K., Fujii, K., Nagao, T., Okada, Y., Toyoda, K., Nakane, H., Sugimori, H., Yamashita, Y., Wakugawa, Y., Asano, K., Tanizaki, Y., Kiyohara, Y., Ibayashi, S., Iida, M.
Format: Artikel
Sprache:eng
Schlagworte:
Aged
Aged, 80 and over
Animals
brain infarction
Brain Ischemia - enzymology
Brain Ischemia - epidemiology
Brain Ischemia - genetics
Cercopithecus aethiops
Cerebral Infarction - enzymology
Cerebral Infarction - epidemiology
Cerebral Infarction - genetics
COS Cells
Female
Gene Frequency - genetics
genetics
Humans
Japan - epidemiology
Male
Middle Aged
NAD(P)H oxidase
NADPH Oxidases - genetics
polymorphism
Polymorphism, Genetic - genetics
Registries
Stroke - enzymology
Stroke - epidemiology
Stroke - genetics
superoxide
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Zusammenfassung:The C242T polymorphism of p22phox, a component of NAD(P)H oxidase, may have an impact on cardiovascular diseases; however, the association between this polymorphism and brain infarction is not fully understood. Here, we investigate the relationship between the C242T polymorphism and brain infarction in Japan. We recruited 1055 patients with brain infarction and 1055 control subjects. A chi‐squared test revealed that the T‐allele frequency was lower in patients with cardioembolic infarction (5.6%) than in control subjects (11.0%, P 
ISSN:1351-5101
1468-1331
DOI:10.1111/j.1468-1331.2007.01904.x