Characterization of CTX-M-22 and TEM-141 Encoded by a Single Plasmid from a Clinical Isolate of Enterobacter cloacae in China

We analyzed the resistance to expanded-spectrum cephalosporins of an Enterobacter cloacae clinical isolate, EC002, by transconjugation, isoelectric-focusing analysis, and cloning experiments. It produced two β-lactamases with isoelectric point values of 5.4 and 8.7, corresponding to TEM-141, a novel...

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Veröffentlicht in:	Japanese Journal of Infectious Diseases 2007/09/27, Vol.60(5), pp.295-297
Hauptverfasser:	Liu, Gang, Ling, Bao-Dong, Xie, Yong-En, Lin, Li, Zeng, Yun, Zhang, Xiang, Lei, Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence beta-Lactam Resistance - genetics beta-Lactamases - genetics beta-Lactamases - metabolism Cephalosporins - pharmacology China Drug Resistance, Bacterial - genetics Enterobacter cloacae - enzymology Enterobacter cloacae - genetics Enterobacter cloacae - isolation & purification Enterobacteriaceae Infections - drug therapy Enterobacteriaceae Infections - microbiology Humans Klebsiella pneumoniae - genetics Molecular Sequence Data Plasmids - genetics
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Zusammenfassung:	We analyzed the resistance to expanded-spectrum cephalosporins of an Enterobacter cloacae clinical isolate, EC002, by transconjugation, isoelectric-focusing analysis, and cloning experiments. It produced two β-lactamases with isoelectric point values of 5.4 and 8.7, corresponding to TEM-141, a novel variant of TEM-1, and CTX-M-22, encoded by a transferable plasmid.
ISSN:	1344-6304 1884-2836
DOI:	10.7883/yoken.JJID.2007.295