Evidence of population mixing based on the geographical distribution of childhood leukemia in Ohio

Background This ecologic study examined the geographic distribution of childhood leukemias in Ohio, 1996–2000, among children aged 0–19 for evidence that population mixing may be a factor. Procedure (1) State incidence rates were compared to Surveillance, Epidemiology and End Results (SEER) rates for each year and for the 5‐year period, 1996–2000; (2) incidence rates for each of Ohio's 88 counties were compared to statewide rates; and (3) county incidence rates were compared based on population density, population growth, and rural/urban locale. SEER*Stat version 5.0 was used to derive age‐specific and 0–19 age‐adjusted rates. Expected values, standardized incidence ratios (SIRs), and Poisson P‐values were calculated with Excel using the indirect method of standardization. Results Of the 585 cases, 73.3% were acute lymphocytic leukemia (ALL), 16.6% acute myelogenous leukemia (AML), 3.2% acute monocytic leukemia (AMoL), and 2.6% chronic myelogenous leukemia (CML). Rates for total leukemia burden were significantly below national levels for all races (P = 0.00001), likely due to poor ascertainment of cases. Yearly incidence rates for 1996–2000 were stable for ALL and AML; CML rates declined over the period. Based on 2000 Census and intercensal population estimates for 1996–2000, statistically higher rates for ALL were noted for counties experiencing >10% population change 1990–2000 (P