Association of Cognitive Impairment with Plasma Levels of Folate, Vitamin B12 and Homocysteine in the Elderly

Association of Cognitive Impairment with Plasma Levels of Folate, Vitamin B12 and Homocysteine in the Elderly

Background: Alterations in folate, vitamin B 12 and homocysteine plasma levels have been associated with aging, neuronal development and cognitive impairment. The aim of this study was to investigate the relationship between plasma folate, vitamin B 12 and homocysteine and cognitive function in the...

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Veröffentlicht in:In vivo (Athens) 2006-11, Vol.20 (6B), p.895-899
Hauptverfasser: Dimopoulos, Nikolaos, Piperi, Christina, Salonicioti, Aristea, Psarra, Vassiliki, Gazi, Flerri, Nounopoulos, Charalambos, Lea, Robert W, Kalofoutis, Anastasios
Format: Artikel
Sprache:eng
Schlagworte:
Aged
Aged, 80 and over
Dementia - blood
Dementia - pathology
Female
Folic Acid - blood
Homocysteine - blood
Humans
Male
Severity of Illness Index
Vitamin B 12 - blood
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Zusammenfassung:Background: Alterations in folate, vitamin B 12 and homocysteine plasma levels have been associated with aging, neuronal development and cognitive impairment. The aim of this study was to investigate the relationship between plasma folate, vitamin B 12 and homocysteine and cognitive function in the elderly. Patients and Methods: Elderly individuals over 60 years of age living in the community, were screened with the Mini-Mental State Examination. The study population was divided into two groups: a) 37 subjects with dementia; and b) 33 healthy controls. Blood samples were analyzed with the use of ELISA, and the results were statistically evaluated at p
ISSN:0258-851X
1791-7549